Current knowledge on biomarkers for contact sensitization and allergic contact dermatitis

• Verfasst von: Koppes, Sjors A. [VerfasserIn]
• Verfasst von: Thierse, Hermann-Josef [VerfasserIn]
• Titel: Current knowledge on biomarkers for contact sensitization and allergic contact dermatitis
• Verf.angabe: Sjors A. Koppes, Kristiane A. Engebretsen, Tove Agner, Irena Angelova‐Fischer, Teresa Berents, Johanna Brandner, Richard Brans, Maja-Lisa Clausen, Edith Hummler, Ivone Jakasa, Ružica Jurakić‐Tončic, Swen M. John, Denis Khnykin, Sonja Molin, Jan O. Holm, Sari Suomela, Hermann-Josef Thierse, Sanja Kezic, Stefan F. Martin and Jacob P. Thyssen
• Umfang: 16 S.
• Fussnoten: Gesehen am 29.05.2018
• Titel Quelle: Enthalten in: Contact dermatitis
• Jahr Quelle: 2017
• Band/Heft Quelle: 77(2017), 1, S. 1-16
• ISSN Quelle: 1600-0536
• DOI: doi:10.1111/cod.12789
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1575799987

Abstract

Contact sensitization is common and affects up to 20% of the general population. The clinical manifestation of contact sensitization is allergic contact dermatitis. This is a clinical expression that is sometimes difficult to distinguish from other types of dermatitis, for example irritant and atopic dermatitis. Several studies have examined the pathogenesis and severity of allergic contact dermatitis by measuring the absence or presence of various biomarkers. In this review, we provide a non-systematic overview of biomarkers that have been studied in allergic contact dermatitis. These include genetic variations and mutations, inflammatory mediators, alarmins, proteases, immunoproteomics, lipids, natural moisturizing factors, tight junctions, and antimicrobial peptides. We conclude that, despite the enormous amount of data, convincing specific biomarkers for allergic contact dermatitis are yet to be described.