Impact of concomitant atrial fibrillation on the prognosis of Takotsubo cardiomyopathy

• Verfasst von: El-Battrawy, Ibrahim [VerfasserIn]
• Verfasst von: Lang, Siegfried [VerfasserIn]
• Verfasst von: Ansari, Uzair [VerfasserIn]
• Verfasst von: Behnes, Michael [VerfasserIn]
• Verfasst von: Hillenbrand, Dennis [VerfasserIn]
• Verfasst von: Schramm, Katja [VerfasserIn]
• Verfasst von: Fastner, Christian [VerfasserIn]
• Verfasst von: Zhou, Xiao-Bo [VerfasserIn]
• Verfasst von: Bill, Verena [VerfasserIn]
• Verfasst von: Hoffmann, Ursula [VerfasserIn]
• Verfasst von: Papavassiliu, Theano [VerfasserIn]
• Verfasst von: Elmas, Elif [VerfasserIn]
• Verfasst von: Haghi, Dariusch [VerfasserIn]
• Verfasst von: Borggrefe, Martin [VerfasserIn]
• Verfasst von: Akın, Ibrahim [VerfasserIn]
• Titel: Impact of concomitant atrial fibrillation on the prognosis of Takotsubo cardiomyopathy
• Verf.angabe: Ibrahim El-Battrawy, Siegfried Lang, Uzair Ansari, Michael Behnes, Dennis Hillenbrand, Katja Schramm, Christian Fastner, Xiaobo Zhou, Verena Bill, Ursula Hoffmann, Theano Papavassiliu, Elif Elmas, Darius Haghi, Martin Borggrefe, and Ibrahim Akin
• Jahr: 2017
• Jahr des Originals: 2016
• Umfang: 5 S.
• Fussnoten: Gesehen am 03.07.2018 ; Online publish-ahead-of-print 4 October 2016
• Titel Quelle: Enthalten in: Europace
• Ort Quelle: Oxford : Oxford Univ. Press, 1999
• Jahr Quelle: 2017
• Band/Heft Quelle: 19(2017), 8, Seite 1288-1292
• ISSN Quelle: 1532-2092
• DOI: doi:10.1093/europace/euw293
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1577234995

Abstract

Aims: Previous studies revealed that patients with Takotsubo cardiomyopathy (TTC) have a higher mortality rate than the general population. Supraventricular tachycardia is a well-known complication of TTC. This study was performed to determine the short- and long-term prognostic impact of atrial fibrillation associated with TTC patients. Methods and results: Our institutional database constituted a collective of 114 patients diagnosed with TTC from 2003 to 2015. The patients were divided into two groups according to the presence (n = 21, 18.4%) or absence (n = 93, 81.5%) of atrial fibrillation. The endpoint was a composite of in-hospital events (thromboembolic events and life-threatening arrhythmias), all-cause mortality, rehospitalization due to heart failure, stroke, and the recurrence of TTC. The in-hospital mortality, 30-day mortality, and long-term mortality were significantly higher in the atrial fibrillation group. Kaplan-Meier analysis indicated a significantly lower event-free survival rate over a mean follow-up of 3 years in the atrial fibrillation group than that in the non-atrial fibrillation group (log-rank, P < 0.01). In a multivariate cox regression analysis, atrial fibrillation (hazard ratio, HR 2.3, 95% confidence interval, CI: 1.1-4.9, P < 0.05) and EF ≤ 35% (HR 2.0, 95% CI: 1.1-3.8, P < 0.05) were the only independent predictors of a primary endpoint. Conclusion: Rates of in-hospital events and short- as well as long-term mortality were significantly higher in TTC patients suffering from atrial fibrillation compared with patients without atrial fibrillation.