Repetitive exposure to a 7 Tesla static magnetic field of mice in utero does not cause alterations in basal emotional and cognitive behavior in adulthood

• Verfasst von: Hoyer, Carolin [VerfasserIn]
• Verfasst von: Gass, Peter [VerfasserIn]
• Titel: Repetitive exposure to a 7 Tesla static magnetic field of mice in utero does not cause alterations in basal emotional and cognitive behavior in adulthood
• Verf.angabe: Carolin Hoyer, Miriam A. Vogt, S. Helene Richter, Gregor Zaun, Yasmin Zahedi, Stefan Maderwald, Mark E. Ladd, Elke Winterhager, Ruth Grümmer, Peter Gass
• Umfang: 7 S.
• Fussnoten: Gesehen am 04.07.2018
• Titel Quelle: Enthalten in: Reproductive toxicology
• Jahr Quelle: 2012
• Band/Heft Quelle: 34(2012), 1, S. 86-92
• ISSN Quelle: 1873-1708
• DOI: doi:10.1016/j.reprotox.2012.03.006
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1577287568

Abstract

In the past three decades, magnetic resonance imaging (MRI) has been increasingly used in obstetrics to aid diagnostics of maternal and fetal conditions and has generally been considered a safe imaging method. However, the development of higher-performance systems employing, for example, stronger fields to improve the technique's diagnostic potential, necessitates on-going safety evaluation. Rodent studies provide an excellent opportunity to investigate not only acute but also long-term effects of magnetic field exposure in a systematic manner, and a behavioral analysis might help to uncover subtler effects which might result from magnetic field exposure of the vulnerable developing brain. We conducted a comprehensive investigation of emotional and cognitive behavior in adult mice which had been repeatedly exposed to a 7 Tesla static magnetic field in utero. Using well-validated tests, we did not observe any adverse behavioral alterations regarding emotional behavior as well as spatial and emotional learning.