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Verfasst von:Jakubovski, Ewgeni [VerfasserIn]   i
Titel:Clinical predictors of long-term outcome in obsessive-compulsive disorder
Verf.angabe:Ewgeni Jakubovski, Juliana B. Diniz, M.D., Ph.D., Carolina Valerio, Victor Fossaluza, M.Sc., Cristina Belotto‐Silva, M.Sc., Ph.D., Clarice Gorenstein, Ph.D., Eurípedes Miguel, M.D., Ph.D., and Roseli G. Shavitt, M.D., Ph.D.
Jahr:2013
Jahr des Originals:2012
Umfang:10 S.
Fussnoten:Published online 25 October 2012 ; Gesehen am 09.07.2018
Titel Quelle:Enthalten in: Depression and anxiety
Ort Quelle:New York, NY [u.a.] : Wiley Interscience, 1996
Jahr Quelle:2013
Band/Heft Quelle:30(2013), 8, Seite 763-772
ISSN Quelle:1520-6394
Abstract:Background The purpose of this study was to investigate demographic and clinical factors associated with the long-term outcome of obsessive-compulsive disorder (OCD). Methods A hundred ninety-six previously untreated patients with DSM-IV criteria OCD completed a 12-week randomized open trial of group cognitive-behavioral therapy (GCBT) or fluoxetine, followed by 21 months of individualized, uncontrolled treatment, according to international guidelines for OCD treatment. OCD severity was assessed using the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) at different times over the follow-up period. Demographics and several clinical variables were assessed at baseline. Results Fifty percent of subjects improved at least 35% from baseline, and 21.3% responded fully (final Y-BOCS score < or = 8). Worse prognosis was associated with earlier age at onset of OCD (P = 0.045), longer duration of illness (P = 0.001) presence of at least one comorbid psychiatric disorder (P = 0.001), comorbidity with a mood disorder (P = 0.002), higher baseline Beck-Depression scores (P = 0.011), positive family history of tics (P = 0.008), and positive family history of anxiety disorders (P = 0.008). Type of initial treatment was not associated with long-term outcome. After correction for multiple testing, the presence of at least one comorbid disorder, the presence of a depressive disorder, and duration of OCD remained significant. Conclusions Patients under cognitive-behavioral or pharmacological treatment improved continuously in the long run, regardless of initial treatment modality or degree of early response, suggesting that OCD patients benefit from continuous treatment. Psychiatric comorbidity, especially depressive disorders, may impair the long-term outcome of OCD patients.
DOI:doi:10.1002/da.22013
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: http://dx.doi.org/10.1002/da.22013
 Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/da.22013
 DOI: https://doi.org/10.1002/da.22013
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Cognitive therapy
 Drug therapy
 Fluoxetine
 Follow-up studies
 Obsessive-compulsive disorder
K10plus-PPN:1577397355
Verknüpfungen:→ Zeitschrift

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