Calcium signaling and transcriptional regulation in cardiomyocytes

• Verfasst von: Dewenter, Matthias [VerfasserIn]
• Verfasst von: Katus, Hugo [VerfasserIn]
• Verfasst von: Backs, Johannes [VerfasserIn]
• Titel: Calcium signaling and transcriptional regulation in cardiomyocytes
• Verf.angabe: Matthias Dewenter, Albert von der Lieth, Hugo A. Katus, Johannes Backs
• E-Jahr: 2017
• Jahr: September 29, 2017
• Umfang: 21 S.
• Fussnoten: Originally published: September 28, 2017 ; Gesehen am 09.07.2018
• Titel Quelle: Enthalten in: Circulation research
• Ort Quelle: New York, NY : Assoc., 1953
• Jahr Quelle: 2017
• Band/Heft Quelle: 121(2017), 8, Seite 1000-1020
• ISSN Quelle: 1524-4571
• DOI: doi:10.1161/CIRCRESAHA.117.310355
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: calcineurin
• Sach-SW: calcium
• Sach-SW: calcium-calmodulin dependent protein kinase II
• Sach-SW: calmodulin
• Sach-SW: excitation transcription coupling
• K10plus-PPN: 1577404718

Abstract

Calcium (Ca2+) is a universal regulator of various cellular functions. In cardiomyocytes, Ca2+ is the central element of excitation-contraction coupling, but also impacts diverse signaling cascades and influences the regulation of gene expression, referred to as excitation-transcription coupling. Disturbances in cellular Ca2+-handling and alterations in Ca2+-dependent gene expression patterns are pivotal characteristics of failing cardiomyocytes, with several excitation-transcription coupling pathways shown to be critically involved in structural and functional remodeling processes. Thus, targeting Ca2+-dependent transcriptional pathways might offer broad therapeutic potential. In this article, we (1) review cytosolic and nuclear Ca2+ dynamics in cardiomyocytes with respect to their impact on Ca2+-dependent signaling, (2) give an overview on Ca2+-dependent transcriptional pathways in cardiomyocytes, and (3) discuss implications of excitation-transcription coupling in the diseased heart.