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Verfasser:Tarantino, Ignazio [VerfasserIn]   i
 Warschkow, René [VerfasserIn]   i
Titel:Elevated preoperative CEA is associated with worse survival in stage I-III rectal cancer patients
Verf.angabe:I. Tarantino, R. Warschkow, M. Worni, K. Merati-Kashani, D. Köberle, B.M. Schmied, S.A. Müller, T. Steffen, T. Cerny and U. Güller
Umfang:9 S.
Fussnoten:Gesehen am 12.07.2018 ; Corrected online 03 July 2012, published online 26 June 2012
Titel Quelle:Enthalten in: British journal of cancer
Jahr Quelle:2012
Band/Heft Quelle:107(2012), 2, S. 266-274
ISSN Quelle:1532-1827
Abstract:Background:The objective of this investigation was to assess whether preoperative carcinoembryonic antigen (CEA) level is an independent predictor of overall survival in rectal cancer patients.Methods:All patients (n=504) undergoing a resection for stage I-III rectal cancer at the Kantonsspital St Gallen were included into a database between 1991 and 2008. The impact of preoperative CEA level on overall survival was assessed using risk-adjusted Cox proportional hazard regression models and propensity score methods.Results:In risk-adjusted Cox proportional hazard regression analyses, preoperative CEA level (hazard ratio (HR): 1.98, 95% confidence interval (CI): 1.36-2.90, P<0.001), distance from anal verge (<5 cm: HR: 1.93, 95% CI: 1.11-3.37; P=0.039), older age (HR: 1.07, 95% CI: 1.05-1.09; P<0.001), lower body mass index (HR: 0.94, 95% CI: 0.89-0.98; P=0.006), advanced tumour stage (stage II HR: 1.41, 95% CI: 0.85-2.32; stage III HR: 2.08, 95% CI: 1.31-3.31; P=0.004), R 1 resection (HR: 5.65, 95% CI: 1.59-20.1; P=0.005) and chronic kidney disease (HR: 2.28, 95% CI: 1.03-5.04; P=0.049) were all predictors for poor overall survival.Conclusion:This is one of the first investigations based on a large cohort of exclusively rectal cancer patients demonstrating that preoperative CEA level is a strong predictor of decreased overall survival. Preoperative CEA should be used as a prognostic factor in the preoperative assessment of rectal cancer patients.
DOI:doi:10.1038/bjc.2012.267
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

: Verlag: http://dx.doi.org/10.1038/bjc.2012.267
 : Verlag: https://www.nature.com/articles/bjc2012267
 : : https://doi.org/10.1038/bjc.2012.267
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1577544870
Verknüpfungen:→ Zeitschrift

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