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Verfasst von:Spallek, Markus Jürgen [VerfasserIn]   i
 Storch, Golo [VerfasserIn]   i
 Trapp, Oliver [VerfasserIn]   i
Titel:Straightforward synthesis of poly(dimethylsiloxane) phases with immobilized (1R)-3-(perfluoroalkanoyl)camphorate metal complexes and their application in enantioselective complexation gas chromatography
Verf.angabe:Markus J. Spallek, Golo Storch, and Oliver Trapp
Umfang:17 S.
Fussnoten:Dedicated to Professor Volker Schurig ; Gesehen am 03.08.2018
Titel Quelle:Enthalten in: European journal of organic chemistry
Jahr Quelle:2012
Band/Heft Quelle:(2012), 21, S. 3929-3945
ISSN Quelle:1099-0690
Abstract:A straightforward synthesis of novel chiral polysiloxane-based metal stationary phases immobilized through a propylenoxy linker (Chirasil-Metal-OC3) to the polymeric backbone is presented. Synthesis was accomplished in six steps with high overall yields starting from commercially available, enantiopure (+)-(1S)-camphorsulfonic acid. Two different approaches towards Chirasil-Metal phases featuring either a propylenoxy or propylenthio linker used for immobilization through hydrosilylation are presented. Furthermore, a new protocol for the fluoroacylation, which is one of the key steps in the synthesis of (1R)-3-(perfluoroalkanoyl)camphorate metal complexes, was developed to improve the isolation and overall yield. The immobilization of (1R,4S)-10-(allyloxy)-3-(heptafluorobutanoyl)camphor - 10-(allyloxy)-hfbc - onto polysiloxanes as well as the incorporation of nickel(II), oxovanadium(IV), europium(III), and lanthanum(III) was characterized by FT ATR IR and NMR spectroscopy. Overall, seven different Chirasil-Metal-OC3 polymers with different separation properties were prepared by metal incorporation and variation of the amount of immobilized (1R,4S)-10-(allyloxy)-3-(heptafluorobutanoyl)camphor (10-allyloxy-hfbc: 3.5, 10.2, and 20.0 %). Their performance in enantioselective complexation gas chromatography was systematically studied and excellent enantioselectivity was found for Chirasil-Nickel-OC3. Separation of 29 small-sized compounds, encompassing, among others, epoxides, substituted alkenes and alkynes as well as alcohols and amides, was achieved with high separation factors α. The synthetic strategy, enantiomer separations and thermal stability (up to 160 °C) demonstrates the versatility of the newly derived Chirasil-Metal-OC3 phases.
DOI:doi:10.1002/ejoc.201200075
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Verlag: http://dx.doi.org/10.1002/ejoc.201200075
 Verlag: https://onlinelibrary.wiley.com/doi/abs/10.1002/ejoc.201200075
 DOI: https://doi.org/10.1002/ejoc.201200075
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:157823378X
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