Meta-analysis and brain imaging data support the involvement of VRK2 (rs2312147) in schizophrenia susceptibility

• Verfasst von: Li, Ming [VerfasserIn]
• Verfasst von: Rietschel, Marcella [VerfasserIn]
• Titel: Meta-analysis and brain imaging data support the involvement of VRK2 (rs2312147) in schizophrenia susceptibility
• Verf.angabe: Ming Li, Yi Wang, Xue-bin Zheng, Masashi Ikeda, Nakao Iwata, Xiong-jian Luo, Siow-Ann Chong, Jimmy Lee, Marcella Rietschel, Fengyu Zhang, Bertram Müller-Myhsok, Sven Cichon, Daniel R.Weinberger, Manuel Mattheisen, Thomas G. Schulze, Nicholas G. Martin, Philip B. Mitchell, Peter R. Schofield, Jian-jun Liu, Bing Su and MooDS Consortium
• E-Jahr: 2012
• Jahr: December 2012
• Umfang: 6 S.
• Fussnoten: Gesehen am 30.10.2018
• Titel Quelle: Enthalten in: Schizophrenia research
• Ort Quelle: Amsterdam [u.a.] : Elsevier Science, 1988
• Jahr Quelle: 2012
• Band/Heft Quelle: 142(2012), 1/3, Seite 200-205
• ISSN Quelle: 1573-2509
• DOI: doi:10.1016/j.schres.2012.10.008
• Datenträger: Online-Ressource
• Sprache: eng
• Bibliogr. Hinweis: Erscheint auch als : Druck-Ausgabe: Meta-analysis and brain imaging data support the involvement of VRK2 (rs2312147) in schizophrenia susceptibility. - 2012
• K10plus-PPN: 1582436142

Abstract

Recent genome-wide association studies have reported a set of schizophrenia susceptibility genes, but many of them await further replications in additional samples. Here we analyzed 5 genome-wide supported variants in a Han Chinese sample, and the variant rs2312147 at VRK2 showed significant association, which was confirmed in the meta-analysis combining multiple Asian and European samples (P = 3.17 × 10− 4, N = 7498). Rs2312147 is also associated with brain structure in healthy subjects, including the total brain volume and the white matter volume. Gene expression analyses indicated an up-regulation of VRK2 in schizophrenia patients. Our data provide further evidence for the contribution of VRK2 to schizophrenia.