Navigation überspringen
Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag

Verfügbarkeit
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Kostareli, Efterpi [VerfasserIn]   i
 Holzinger, Dana [VerfasserIn]   i
 Heß, Jochen [VerfasserIn]   i
Titel:New concepts for translational head and neck oncology
Titelzusatz:lessons from HPV-related oropharyngeal squamous cell carcinomas
Verf.angabe:Efterpi Kostareli, Dana Holzinger, and Jochen Hess
E-Jahr:2012
Jahr:11 April 2012
Umfang:10 S.
Fussnoten:Gesehen am 05.11.2018
Titel Quelle:Enthalten in: Frontiers in oncology
Ort Quelle:Lausanne : Frontiers Media, 2011
Jahr Quelle:2012
Band/Heft Quelle:2(2012), Artikel-ID 36, Seite 1-10
ISSN Quelle:2234-943X
Abstract:Human papillomavirus (HPV) infection is well established as etiological agent responsible for a number of pathologies affecting the stratified epithelia of skin and anogenital sites. More recently, the infection by (mucosal) high-risk HPV types has also been found to be causally associated with squamous cell carcinoma in the head and neck region (HNSCC), especially in the oropharynx. Intriguingly, HPV-related oropharyngeal squamous cell carcinomas (OPSCC) represent a distinct clinical entity compared to HPV-negative tumors with regard to treatment response and survival outcome, and the association between HPV infection and OPSCC has potential important implications for prevention and treatment decision making. The improved survival of patients with HPV-related tumors also raises the question, whether a better understanding of the underlying differences may guide us to identify new therapeutic concepts that could be used in targeted therapy for HPV-negative and improved therapy for HPV-positive cancers, and finally to initiate individualization of treatment based on the biology of OPSCC. This review summarizes the most recent advances in our understanding of the molecular principles of HPV-related OPSCC mainly based on functional genomic approaches, but also emphasizes the significant role played by the tumor microenvironment, especially the immune system, for improved clinical outcome and differential sensitivity of HPV-related tumors to current treatment options.
DOI:doi:10.3389/fonc.2012.00036
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: http://dx.doi.org/10.3389/fonc.2012.00036
 Volltext: https://www.frontiersin.org/articles/10.3389/fonc.2012.00036/full
 DOI: https://doi.org/10.3389/fonc.2012.00036
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:epigenome
 Genome
 HNSCC
 HPV
 OPSCC
 Transcriptome
K10plus-PPN:1582562229
Verknüpfungen:→ Zeitschrift

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/68324668   QR-Code
zum Seitenanfang