Decreased axon flare reaction to electrical stimulation in patients with chronic demyelinating inflammatory polyneuropathy

• Verfasst von: Kokotis, Panagiotis [VerfasserIn]
• Verfasst von: Schmelz, Martin [VerfasserIn]
• Verfasst von: Papagianni, Aikaterini [VerfasserIn]
• Verfasst von: Zambelis, Thomas [VerfasserIn]
• Verfasst von: Karandreas, Nikos [VerfasserIn]
• Titel: Decreased axon flare reaction to electrical stimulation in patients with chronic demyelinating inflammatory polyneuropathy
• Verf.angabe: Panagiotis Kokotis, Martin Schmelz, Aikaterini E. Papagianni, Thomas Zambelis, and Nikos Karandreas
• E-Jahr: 2017
• Jahr: 2017/03/01
• Umfang: 6 S.
• Fussnoten: Gesehen am 08.11.2018
• Titel Quelle: Enthalten in: Journal of clinical neurophysiology
• Ort Quelle: Philadelphia, Pa. : Lippincott Williams & Wilkins, 1984
• Jahr Quelle: 2017
• Band/Heft Quelle: 34(2017), 2, Seite 101-106
• ISSN Quelle: 1537-1603
• DOI: doi:10.1097/WNP.0000000000000294
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1582727929

Abstract

Purpose: In chronic inflammatory demyelinating polyradiculopathy (CIDP), the impairment of unmyelinated nerve fibers appears unexpected. The measurement of the electrically induced axon flare reflex is a clinical test to assess the peripheral C-nociceptor function. In this study, we compared the flare area in patients suffering from CIDP with healthy subjects. Methods: We examined 18 patients fulfilling the criteria for CIDP (11 men, mean age 51.8 years, SD 15.1) and 18 age-matched adult healthy volunteers (control group) (11 men, mean age 51.9 years, SD 15.8). The flare responses were elicited by transcutaneous electrical stimulation and recorded by laser Doppler imaging. Results: There was a significant reduction of electrically induced maximum flare area in the foot dorsum of patients with CIDP (t-value 2.08, P = 0.04) which proved to be length-dependent measured by a numerical index comparing the results with the forearm and thigh. The repeatedmeasures ANOVA revealed statistically significant smaller flare areas in all body regions for the CIDP group (P < 0.001). Conclusions: The axon flare reaction to electrical stimulation was decreased in patients with chronic demyelinating inflammatory polyneuropathy. The evaluation of the axon flare response can be proposed as a noninvasive objective functional test to detect an impaired C-fiber function in CIDP patients with the advantages of simplicity of the procedure, time economy, and objectivity.