MondoA is highly overexpressed in acute lymphoblastic leukemia cells and modulates their metabolism, differentiation and survival

• Verfasst von: Wernicke, Caroline [VerfasserIn]
• Verfasst von: Bandapalli, Obul Reddy [VerfasserIn]
• Titel: MondoA is highly overexpressed in acute lymphoblastic leukemia cells and modulates their metabolism, differentiation and survival
• Verf.angabe: Caroline M. Wernicke, Günther H.S. Richter, Beate C. Beinvogl, Stephanie Plehm, Anna M. Schlitter, Obul R. Bandapalli, Olivia Prazeres da Costa, Uwe E. Hattenhorst, Ines Volkmer, Martin S. Staege, Irene Esposito, Stefan Burdach, Thomas G.P. Grunewald
• E-Jahr: 2012
• Jahr: September 2012
• Umfang: 8 S.
• Fussnoten: Gesehen am 26.11.2018
• Titel Quelle: Enthalten in: Leukemia research
• Ort Quelle: Amsterdam [u.a.] : Elsevier Science, 1977
• Jahr Quelle: 2012
• Band/Heft Quelle: 36(2012), 9, Seite 1185-1192
• ISSN Quelle: 1873-5835
• DOI: doi:10.1016/j.leukres.2012.05.009
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Clonogenicity
• Sach-SW: Differentiation
• Sach-SW: Leukemia
• Sach-SW: Metabolism
• Sach-SW: MondoA
• Sach-SW: MondoB
• Sach-SW: Survival
• K10plus-PPN: 1584442549

Abstract

Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. To identify novel candidates for targeted therapy, we performed a comprehensive transcriptome analysis identifying MondoA (MLXIP) - a transcription factor regulating glycolysis - to be overexpressed in ALL compared to normal tissues. Using microarray-profiling, gene-set enrichment analysis, RNA interference and functional assays we show that MondoA overexpression increases glucose catabolism and maintains a more immature phenotype, which is associated with enhanced survival and clonogenicity of leukemia cells. These data point to an important contribution of MondoA to leukemia aggressiveness and make MondoA a potential candidate for targeted treatment of ALL.