Vitamin D and mortality

• Verfasst von: Pilz, Stefan [VerfasserIn]
• Verfasst von: März, Winfried [VerfasserIn]
• Titel: Vitamin D and mortality
• Verf.angabe: Stefan Pilz, Martin Grübler, Martin Gaksch, Verena Schwetz, Christian Trummer, Bríain Ó Hartaigh, Nicolas Verheyen, Andreas Tomaschitz and Winfried März
• E-Jahr: 2016
• Jahr: March 2016
• Umfang: 9 S.
• Fussnoten: Gesehen am 06.03.2019
• Titel Quelle: Enthalten in: Anticancer research
• Ort Quelle: Kapandriti, Attiki, Greece : International Institute of Anticancer Research, 2004
• Jahr Quelle: 2016
• Band/Heft Quelle: 36(2016), 3, Seite 1379-1387
• ISSN Quelle: 1791-7530
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: review
• Sach-SW: 25(OH)D
• Sach-SW: epidemiology
• Sach-SW: mortality
• Sach-SW: RCT
• Sach-SW: Vitamin D
• K10plus-PPN: 158839297X

Abstract

In this narrative review, we aim to summarize and discuss the current evidence linking vitamin D and mortality. Low 25-hydroxyvitamin D [25(OH)D] concentrations are associated with an increased risk of mortality. This has been shown in different cohort studies including general populations, as well as various patient cohorts. Some single-study results and meta-analyses indicate that the shape of the relationship between 25(OH)D and mortality follows a U- or a reverse J-shaped curve. Interassay and laboratory differences are, however, a limitation of most previous surveys, and standardization of 25(OH)D measurements is needed for future investigations. Apart from observational data, it has been documented in meta-analyses of randomized controlled trials that vitamin D3 supplementation is associated with a moderate, yet statistically significant, reduction in mortality. This latter finding must be interpreted in light of some limitations such as incomplete follow-up data, but such a reduction of mortality with vitamin D3 supplementation as the finding of meta-analyses of randomized controlled trials strongly argues for the benefits and, importantly, also the safety of vitamin D.