Human pigmentation, cutaneous vitamin D synthesis and evolution

• Verfasst von: Roßberg, Willi [VerfasserIn]
• Verfasst von: Kleber, Marcus E. [VerfasserIn]
• Verfasst von: März, Winfried [VerfasserIn]
• Titel: Human pigmentation, cutaneous vitamin D synthesis and evolution
• Titelzusatz: variants of genes (SNPs) involved in skin pigmentation are associated with 25(OH)D serum concentration
• Verf.angabe: Willi Rossberg, Roman Saternus, Stefan Wagenpfeil, Marcus Kleber, Winfried März, Sandra Reichrath, Thomas Vogt and Jörg Reichrath
• E-Jahr: 2016
• Jahr: March 2016
• Umfang: 9 S.
• Fussnoten: Gesehen am 06.03.2019
• Titel Quelle: Enthalten in: Anticancer research
• Ort Quelle: Kapandriti, Attiki, Greece : International Institute of Anticancer Research, 2004
• Jahr Quelle: 2016
• Band/Heft Quelle: 36(2016), 3, Seite 1429-1437
• ISSN Quelle: 1791-7530
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Human pigmentation
• Sach-SW: melanocytes
• Sach-SW: SNPs
• Sach-SW: sunlight
• Sach-SW: vitamin D
• K10plus-PPN: 1588398269

Abstract

Vitamin D deficiency is common and associated with higher risk for and unfavourable outcome of many diseases. Limited data exist on genetic determinants of serum 25(OH)D concentration. In a cohort of the LURIC study (n=2974, median 25(OH)D concentration 15.5 ng/ml), we tested the hypothesis that variants (SNPs, n=244) of several genes (n=15) involved in different aspects of skin pigmentation, including melanosomal biogenesis (ATP7A, DTNBP1, BLOC1S5, PLDN, PMEL), melanosomal transport within melanocytes (RAB27A, MYO5A, MLPH); or various melanocyte signaling pathways (MC1R, MITF, PAX3, SOX10, DKK1, RACK1, CNR1) are predictive of serum 25(OH)D levels. Eleven SNPs located in 6 genes were associated (p<0.05) with low or high serum 25(OH)D levels, 3 out of these 11 SNPs reached the aimed significance level after correction for multiple comparisons (FDR). In the linear regression model adjusted for sex, body mass index (BMI), year of birth and month of blood sample rs7565264 (MLPH), rs10932949 (PAX3), and rs9328451 (BLOC1S5) showed a significant association with 25(OH)D. The combined impact on variation of 25(OH)D serum levels (coefficient of determination (R2)) for the 11 SNPs was 1.6% and for the 3 SNPs after FDR 0.3%. In Cox Regression we identified rs2292881 (MLPH) as having a significant association (advantage) with overall survival. Kaplan-Meier analysis did not show any significant impact of individual SNPs on overall survival. In conclusion, these results shed new light on the role of sunlight, skin pigmentation and vitamin D for human evolution.