Navigation überspringen
Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag

Verfügbarkeit
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Eisele, Philipp [VerfasserIn]   i
 Szabo, Kristina [VerfasserIn]   i
 Ebert, Anne [VerfasserIn]   i
 Roßmanith, Christina [VerfasserIn]   i
 Paschke, Nadia [VerfasserIn]   i
 Platten, Michael [VerfasserIn]   i
 Schönberg, Stefan [VerfasserIn]   i
 Schad, Lothar R. [VerfasserIn]   i
 Gass, Achim [VerfasserIn]   i
Titel:Temporal evolution of acute multiple sclerosis lesions on serial sodium (23Na) MRI
Verf.angabe:Philipp Eisele, Simon Konstandin, Kristina Szabo, Anne Ebert, Christina Roßmanith, Nadia Paschke, Martin Kerschensteiner, Michael Platten, Stefan O. Schoenberg, Lothar R. Schad, Achim Gass
E-Jahr:2019
Jahr:April 2019
Umfang:7 S.
Fussnoten:Gesehen am 03.04.2019 ; Im Titel ist "23" hochgestellt
Titel Quelle:Enthalten in: Multiple Sclerosis and Related Disorders
Ort Quelle:Amsterdam [u.a.] : Elsevier, 2012
Jahr Quelle:2019
Band/Heft Quelle:29(2019), Seite 48-54
ISSN Quelle:2211-0356
Abstract:Background - Several studies have reported the characteristics of acute multiple sclerosis (MS) lesions on diffusion-weighted magnetic resonance imaging (DWI MRI). Current publications reported a transient reduction of the apparent diffusion coefficient (ADC) delineating an early phase of lesion evolution, before increased diffusion occurs in parallel to blood-brain-barrier (BBB) breakdown. Sodium MRI might provide another perspective on lesion development, but clinical applications have been limited to high field MR systems. The objective in this study was to investigate the temporal evolution of acute MS lesions using conventional (T2-fluid-attenuated inversion recovery (T2-FLAIR) images, post-contrast T1-weighted images), diffusion and sodium MRI. - Methods - Initial and follow-up MRI (23Na and 1H MRI) were performed on a 3T scanner. Quantitative assessment of total sodium concentration (TSC) and ADC was performed. The study was designed for frequent follow-up MRI examinations during 4 weeks after the initial presentation. - Results - Thirty-one acute MS lesions (7 lesions with reduced diffusion) in eleven MS patients were included. On initial MRI, TSC in contrast-enhancing lesions was increased when compared to the normal-appearing white matter (NAWM), while lesions with an initial reduced diffusion showed a TSC comparable to the NAWM. On follow-up MRI, in lesions with reduced diffusion subsequent increase of ADC and TSC values occurred along with signs of the development of vasogenic edema and contrast-enhancement. After four weeks, TSC values decreased along with regression of vasogenic edema and contrast-enhancement. - Conclusions - In lesions with a reduction of the ADC sodium levels are near normal and precede signs of BBB breakdown. These findings suggest a relatively preserved tissue structure in this early phase of lesion evolution.
DOI:doi:10.1016/j.msard.2019.01.027
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1016/j.msard.2019.01.027
 Volltext: http://www.sciencedirect.com/science/article/pii/S2211034819300276
 DOI: https://doi.org/10.1016/j.msard.2019.01.027
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Diffusion
 MRI
 Multiple sclerosis
 Na
 Sodium
K10plus-PPN:1662784163
Verknüpfungen:→ Zeitschrift

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/68378397   QR-Code
zum Seitenanfang