Cognitive effects of high-frequency rTMS in schizophrenia patients with predominant negative symptoms

• Verfasst von: Hasan, Alkomiet [VerfasserIn]
• Verfasst von: Rietschel, Marcella [VerfasserIn]
• Titel: Cognitive effects of high-frequency rTMS in schizophrenia patients with predominant negative symptoms
• Titelzusatz: results from a multicenter randomized sham-controlled trial
• Verf.angabe: Alkomiet Hasan, Birgit Guse, Joachim Cordes, Wolfgang Wölwer, Georg Winterer, Wolfgang Gaebel, Berthold Langguth, Michael Landgrebe, Peter Eichhammer, Elmar Frank, Göran Hajak, Christian Ohmann, Pablo E. Verde, Marcella Rietschel, Raees Ahmed, William G. Honer, Berend Malchow, Susanne Karch, Thomas Schneider-Axmann, Peter Falkai, and Thomas Wobrock
• Jahr: 2016
• Jahr des Originals: 2015
• Umfang: 11 S.
• Fussnoten: Gesehen am 07.05.2019 ; Advance Access publication October 3, 2015
• Titel Quelle: Enthalten in: Schizophrenia bulletin
• Ort Quelle: Oxford : Oxford Univ. Press, 1969
• Jahr Quelle: 2016
• Band/Heft Quelle: 42(2016), 3, Seite 608-618
• ISSN Quelle: 1745-1701
• DOI: doi:10.1093/schbul/sbv142
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1664856188

Abstract

Cognitive impairments are one of the main contributors to disability and poor long-term outcome in schizophrenia. Proof-of-concept trials indicate that repetitive transcranial magnetic stimulation (rTMS) applied to the left dorsolateral prefrontal cortex (DLPFC) has the potential to improve cognitive functioning. We analyzed the effects of 10-Hz rTMS to the left DLPFC on cognitive deficits in schizophrenia in a large-scale and multicenter, sham-controlled study. A total of 156 schizophrenia patients with predominant negative symptoms were randomly assigned to a 3-week intervention (10-Hz rTMS, 15 sessions, 1000 stimuli per session) with either active or sham rTMS. The Rey Auditory Verbal Learning Test, Trail Making Test A and B, Wisconsin Card Sorting Test, Digit Span Test, and the Regensburg Word Fluency Test were administered before intervention and at day 21, 45, and 105 follow-up. From the test results, a neuropsychological composite score was computed. Both groups showed no differences in any of the outcome variables before and after intervention. Both groups improved markedly over time, but effect sizes indicate a numeric, but nonsignificant superiority of active rTMS in certain cognitive tests. Active 10-Hz rTMS applied to the left DLPFC for 3 weeks was not superior to sham rTMS in the improvement of various cognitive domains in schizophrenia patients with predominant negative symptoms. This is in contrast to previous preliminary proof-of-concept trials, but highlights the need for more multicenter randomized controlled trials in the field of noninvasive brain stimulation.