Circulating 25-hydroxy-vitamin D and risk of cardiovascular disease

• Verfasst von: Wang, Lu [VerfasserIn]
• Verfasst von: Song, Yiqing [VerfasserIn]
• Verfasst von: Pilz, Stefan [VerfasserIn]
• Verfasst von: März, Winfried [VerfasserIn]
• Titel: Circulating 25-hydroxy-vitamin D and risk of cardiovascular disease
• Verf.angabe: Wang Lu, Song Yiqing, Manson JoAnn E., Pilz Stefan, März Winfried, Michaëlsson Karl, Lundqvist Annamari, Jassal Simerjot K., Barrett-Connor Elizabeth, Zhang Cuilin, Eaton Charles B., May Heidi T., Anderson Jeffrey L., Sesso Howard D.
• E-Jahr: 2012
• Jahr: November 2012
• Umfang: 11 S.
• Fussnoten: Gesehen am 08.05.2019
• Titel Quelle: Enthalten in: Circulation. Cardiovascular quality and outcomes
• Ort Quelle: Philadelphia, Pa. : Lippincott, Williams & Wilkins, 2008
• Jahr Quelle: 2012
• Band/Heft Quelle: 5(2012), 6, Seite 819-829
• ISSN Quelle: 1941-7705
• DOI: doi:10.1161/CIRCOUTCOMES.112.967604
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1664979212

Abstract

Background—Vitamin D status has been linked to the risk of cardiovascular disease (CVD). However, the optimal 25-hydroxy-vitamin D (25[OH]-vitamin D) levels for potential cardiovascular health benefits remain unclear.Methods and Results—We searched MEDLINE and EMBASE from 1966 through February 2012 for prospective studies that assessed the association of 25(OH)-vitamin D concentrations with CVD risk. A total of 24 articles met our inclusion criteria, from which 19 independent studies with 6123 CVD cases in 65 994 participants were included for a meta-analysis. In a comparison of the lowest with the highest 25(OH)-vitamin D categories, the pooled relative risk was 1.52 (95% confidence interval, 1.30-1.77) for total CVD, 1.42 (95% confidence interval, 1.19-1.71) for CVD mortality, 1.38 (95% confidence interval, 1.21-1.57) for coronary heart disease, and 1.64 (95% confidence interval, 1.27-2.10) for stroke. These associations remained strong and significant when analyses were limited to studies that excluded participants with baseline CVD and were better controlled for season and confounding. We used a fractional polynomial spline regression analysis to assess the linearity of dose-response association between continuous 25(OH)-vitamin D and CVD risk. The CVD risk increased monotonically across decreasing 25(OH)-vitamin D below ≈60 nmol/L, with a relative risk of 1.03 (95% confidence interval, 1.00-1.06) per 25-nmol/L decrement in 25(OH)-vitamin D.Conclusions—This meta-analysis demonstrated a generally linear, inverse association between circulating 25(OH)-vitamin D ranging from 20 to 60 nmol/L and risk of CVD. Further research is needed to clarify the association of 25(OH)-vitamin D higher than 60 nmol/L with CVD risk and assess causality of the observed associations.