| |  Online-Ressource |
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| Verfasst von: | Oettl, Lars-Lennart [VerfasserIn]  |
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| | Schneider, Miriam [VerfasserIn] |
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| | Meyer-Lindenberg, Andreas [VerfasserIn] |
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| | Grinevich, Valéry [VerfasserIn] |
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| | Kelsch, Wolfgang [VerfasserIn] |
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| Titel: | Oxytocin enhances social recognition by modulating cortical control of early olfactory processing |
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| Verf.angabe: | Lars-Lennart Oettl, Namasivayam Ravi, Miriam Schneider, Max F. Scheller, Peggy Schneider, Mariela Mitre, Miriam da Silva Gouveia, Robert C. Froemke, Moses V. Chao, W. Scott Young, Andreas Meyer-Lindenberg, Valery Grinevich, Roman Shusterman, and Wolfgang Kelsch |
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| E-Jahr: | 2016 |
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| Jahr: | April 21, 2016 |
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| Umfang: | 13 S. |
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| Fussnoten: | Gesehen am 09.05.2019 |
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| Titel Quelle: | Enthalten in: Neuron |
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| Ort Quelle: | [Cambridge, Mass.] : Cell Press, 1988 |
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| Jahr Quelle: | 2016 |
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| Band/Heft Quelle: | 90(2016), 3, Seite 609-621 |
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| ISSN Quelle: | 1097-4199 |
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| Abstract: | Oxytocin promotes social interactions and recognition of conspecifics that rely on olfaction in most species. The circuit mechanisms through which oxytocin modifies olfactory processing are incompletely understood. Here, we observed that optogenetically induced oxytocin release enhanced olfactory exploration and same-sex recognition of adult rats. Consistent with oxytocin’s function in the anterior olfactory cortex, particularly in social cue processing, region-selective receptor deletion impaired social recognition but left odor discrimination and recognition intact outside a social context. Oxytocin transiently increased the drive of the anterior olfactory cortex projecting to olfactory bulb interneurons. Cortical top-down recruitment of interneurons dynamically enhanced the inhibitory input to olfactory bulb projection neurons and increased the signal-to-noise of their output. In summary, oxytocin generates states for optimized information extraction in an early cortical top-down network that is required for social interactions with potential implications for sensory processing deficits in autism spectrum disorders. |
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| DOI: | doi:10.1016/j.neuron.2016.03.033 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.neuron.2016.03.033 |
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| | Volltext: http://www.sciencedirect.com/science/article/pii/S0896627316300241 |
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| | DOI: https://doi.org/10.1016/j.neuron.2016.03.033 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | anterior olfactory nucleus |
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| | centrifugal |
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| | granule cells |
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| | mitral cells |
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| K10plus-PPN: | 1665067039 |
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| Verknüpfungen: | → Zeitschrift |
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Oxytocin enhances social recognition by modulating cortical control of early olfactory processing / Oettl, Lars-Lennart [VerfasserIn]; April 21, 2016 (Online-Ressource)
