| Online-Ressource |
Verfasst von: | Eliava, Marina [VerfasserIn]  |
| Silva Gouveia, Miriam da [VerfasserIn]  |
| Althammer, Ferdinand [VerfasserIn]  |
| Chini, Bice [VerfasserIn]  |
| Tan, Linette Liqi [VerfasserIn]  |
| Kuner, Rohini [VerfasserIn]  |
| Grinevich, Valéry [VerfasserIn]  |
Titel: | A new population of parvocellular oxytocin neurons controlling magnocellular neuron activity and inflammatory pain processing |
Verf.angabe: | Marina Eliava, Meggane Melchior, H. Sophie Knobloch-Bollmann, Jérôme Wahis, Miriam da Silva Gouveia, Yan Tang, Alexandru Cristian Ciobanu, Rodrigo Triana del Rio, Lena C. Roth, Ferdinand Althammer, Virginie Chavant, Yannick Goumon, Tim Gruber, Nathalie Petit-Demoulière, Marta Busnelli, Bice Chini, Linette L. Tan, Mariela Mitre, Robert C. Froemke, Moses V. Chao, Günter Giese, Rolf Sprengel, Rohini Kuner, Pierrick Poisbeau, Peter H. Seeburg, Ron Stoop, Alexandre Charlet, Valery Grinevich |
E-Jahr: | 2016 |
Jahr: | 3 March 2016 |
Umfang: | 14 S. |
Fussnoten: | Gesehen am 13.05.2019 |
Titel Quelle: | Enthalten in: Neuron |
Ort Quelle: | [Cambridge, Mass.] : Cell Press, 1988 |
Jahr Quelle: | 2016 |
Band/Heft Quelle: | 89(2016), 6, Seite 1291-1304 |
ISSN Quelle: | 1097-4199 |
Abstract: | Summary - Oxytocin (OT) is a neuropeptide elaborated by the hypothalamic paraventricular (PVN) and supraoptic (SON) nuclei. Magnocellular OT neurons of these nuclei innervate numerous forebrain regions and release OT into the blood from the posterior pituitary. The PVN also harbors parvocellular OT cells that project to the brainstem and spinal cord, but their function has not been directly assessed. Here, we identified a subset of approximately 30 parvocellular OT neurons, with collateral projections onto magnocellular OT neurons and neurons of deep layers of the spinal cord. Evoked OT release from these OT neurons suppresses nociception and promotes analgesia in an animal model of inflammatory pain. Our findings identify a new population of OT neurons that modulates nociception in a two tier process: (1) directly by release of OT from axons onto sensory spinal cord neurons and inhibiting their activity and (2) indirectly by stimulating OT release from SON neurons into the periphery. |
DOI: | doi:10.1016/j.neuron.2016.01.041 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/j.neuron.2016.01.041 |
| Volltext: http://www.sciencedirect.com/science/article/pii/S089662731600088X |
| DOI: https://doi.org/10.1016/j.neuron.2016.01.041 |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1665314206 |
Verknüpfungen: | → Zeitschrift |
¬A¬ new population of parvocellular oxytocin neurons controlling magnocellular neuron activity and inflammatory pain processing / Eliava, Marina [VerfasserIn]; 3 March 2016 (Online-Ressource)