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| Verfasst von: | Kölsche, Christian [VerfasserIn]  |
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| | Kriegsmann, Mark [VerfasserIn] |
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| | Kommoss, Felix [VerfasserIn] |
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| | Stichel, Damian [VerfasserIn] |
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| | Pfister, Stefan [VerfasserIn] |
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| | Jones, David T. W. [VerfasserIn] |
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| | Mechtersheimer, Gunhild [VerfasserIn] |
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| | Deimling, Andreas von [VerfasserIn] |
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| Titel: | DNA methylation profiling distinguishes Ewing-like sarcoma with EWSR1-NFATc2 fusion from Ewing sarcoma |
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| Verf.angabe: | Christian Koelsche, Mark Kriegsmann, Felix K. F. Kommoss, Damian Stichel, Katharina Kriegsmann, Christian Vokuhl, Thomas G. P. Grünewald, Laura Romero-Pérez, Thomas Kirchner, Enrique de Alava, Juan Diaz-Martin, Wolfgang Hartmann, Daniel Baumhoer, Cristina R. Antonescu, Karoly Szuhai, Uta Flucke, Uta Dirksen, Stefan M. Pfister, David T. W. Jones, Gunhild Mechtersheimer, Andreas von Deimling |
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| E-Jahr: | 2019 |
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| Jahr: | 20 March 2019 |
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| Umfang: | 9 S. |
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| Fussnoten: | Gesehen am 04.07.2019 |
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| Titel Quelle: | Enthalten in: Journal of cancer research and clinical oncology |
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| Ort Quelle: | Berlin : Springer, 1904 |
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| Jahr Quelle: | 2019 |
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| Band/Heft Quelle: | 145(2019), 5, Seite 1273-1281 |
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| ISSN Quelle: | 1432-1335 |
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| Abstract: | PurposeRecent studies revealed divergent gene expression patterns in Ewing sarcoma (EwS) with canonical EWSR1-ETS gene fusions and undifferentiated round cell sarcomas (URCS) with EWSR1 rearrangements fused to the non-ETS gene NFATc2. Thus, the question arises whether the latter tumors really belong to EwS.MethodsWe collected five cases matching the group of URCS with EWSR1-NFATc2 fusion and performed DNA methylation and copy number profiling. Results were compared to methylation data of 30 EwS with various EWSR1-ETS fusions and one EwS with FUS-ERG fusion, 16 URCS with CIC rearrangement and 10 URCS with BCOR alteration and a total of 81 EWSR1-associated soft tissue sarcomas including 7 angiomatoid fibrous histiocytomas, 7 clear cell sarcomas of the soft tissue, 28 desmoplastic small round cell tumors, 10 extraskeletal myxoid chondrosarcomas and 29 myxoid liposarcomas.ResultsUnsupervised hierarchical clustering and t-distributed stochastic neighbor embedding analysis of DNA methylation data revealed a homogeneous methylation cluster for URCS with EWSR1-NFATc2 fusion, which clearly segregated from EwS and the other subtypes. Copy number profiles of EWSR1-NFATc2 cases showed recurrent losses on chromosome 9q and segmental gains on 20q13 and 22q12 involving the EWSR1 and NFATc2 loci, respectively.ConclusionIn summary, URCS with EWSR1-NFATc2 fusion share a distinct DNA methylation signature and carry characteristic copy number alterations, which emphasizes that these sarcomas should be considered separately from EwS. |
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| DOI: | doi:10.1007/s00432-019-02895-2 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1007/s00432-019-02895-2 |
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| | DOI: https://doi.org/10.1007/s00432-019-02895-2 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | DNA methylation |
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| | Ewing |
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| | Ewing like |
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| | EWSR1 |
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| | NFATc2 |
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| K10plus-PPN: | 1668600056 |
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| Verknüpfungen: | → Zeitschrift |
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DNA methylation profiling distinguishes Ewing-like sarcoma with EWSR1-NFATc2 fusion from Ewing sarcoma / Kölsche, Christian [VerfasserIn]; 20 March 2019 (Online-Ressource)
