The cellular antiviral restriction factor tetherin does not inhibit poxviral replication

• Verfasst von: Sliva, Katja [VerfasserIn]
• Verfasst von: Laqmani-Goffinet, Christine [VerfasserIn]
• Verfasst von: Keppler, Oliver Till [VerfasserIn]
• Titel: The cellular antiviral restriction factor tetherin does not inhibit poxviral replication
• Verf.angabe: Katja Sliva, Theresa Resch, Benjamin Kraus, Christine Goffinet, Oliver T. Keppler, and Barbara S. Schnierle
• Jahr: 2012
• Jahr des Originals: 2011
• Umfang: 4 S.
• Fussnoten: Published ahead of print 16 November 2011 ; Gesehen am 09.07.2019
• Titel Quelle: Enthalten in: Journal of virology
• Ort Quelle: Baltimore, Md. : Soc., 1967
• Jahr Quelle: 2012
• Band/Heft Quelle: 86(2012), 3, Seite 1893-1896
• ISSN Quelle: 1098-5514
• DOI: doi:10.1128/JVI.05198-11
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Antigens, CD
• Sach-SW: Cell Line
• Sach-SW: GPI-Linked Proteins
• Sach-SW: Humans
• Sach-SW: Vaccinia virus
• Sach-SW: Virus Replication
• K10plus-PPN: 1668830965

Abstract

Interferon-stimulated genes fulfill innate antiviral effector functions. Among them, tetherin (THN) blocks the release of many enveloped viruses from infected cells. Vaccinia virus (VACV) encodes immune modulators interfering with antiviral host responses. Therefore, it was tempting to study a potential VACV-THN interaction. Remarkably, THN expression did not inhibit VACV release and replication. VACV infection did not diminish THN surface levels or impair its function on retroviral release. This suggests that THN is unable to restrict VACV replication.