Antipsychotikaassoziierte motorische Symptome bei schizophrenen Psychosen

• Verfasst von: Hirjak, Dusan [VerfasserIn]
• Verfasst von: Sartorius, Alexander [VerfasserIn]
• Verfasst von: Kubera, Katharina Maria [VerfasserIn]
• Verfasst von: Wolf, Robert Christian [VerfasserIn]
• Titel: Antipsychotikaassoziierte motorische Symptome bei schizophrenen Psychosen
• Titelzusatz: Teil 2 : Katatone Symptome und malignes neuroleptisches Syndrom
• Paralleltitel: Antipsychotic-inducedmotor symptoms in schizophrenic psychoses
• Paralleltitelzusatz: Part 2 : Catatonic symptoms and neuroleptic malignant syndrome
• Verf.angabe: D. Hirjak, A. Sartorius, K.M. Kubera, R.C. Wolf
• Jahr: 2019
• Jahr des Originals: 2018
• Umfang: 13 S.
• Fussnoten: Online publiziert: 20. August 2018 ; Gesehen am 18.07.2019
• Titel Quelle: Enthalten in: Der Nervenarzt
• Ort Quelle: Berlin : Springer, 1996
• Jahr Quelle: 2019
• Band/Heft Quelle: 90(2019), 1, Seite 12-24
• ISSN Quelle: 1433-0407
• DOI: doi:10.1007/s00115-018-0581-6
• Datenträger: Online-Ressource
• Sprache: ger eng
• Sach-SW: Antipsychotic-associated catatonia
• Sach-SW: Antipsychotikaassoziierte Katatonie
• Sach-SW: Catatonia
• Sach-SW: Differentialdiagnosis
• Sach-SW: Differenzialdiagnosen
• Sach-SW: Katatonie
• Sach-SW: Malignes neuroleptisches Syndrom
• Sach-SW: Neuroleptic malignant syndrome
• Sach-SW: Therapie
• Sach-SW: Therapy
• K10plus-PPN: 1669398943

Abstract

In rare cases, pharmacotherapy in schizophrenic psychoses can be associated with life-threatening antipsychotic-induced movement disorders. The two most severe complications are antipsychotic-associated catatonic symptoms (ACS) and neuroleptic malignant syndrome (NMS). Although both constellations necessitate rapid medical care, the diagnosis is still a clinical challenge. Although there is no established treatment of ACS (here designated as a specific subtype of catatonic symptoms), an attempt should be made with benzodiazepines and memantine can also be helpful. In severe drug-refractory cases electroconvulsive therapy (ECT) can be indicated. The NMS represents a life-threatening constellation that frequently requires intensive care unit treatment. The medicinal treatment with benzodiazepines, bromocriptine, amantadine, dantrolene and/or ECT is also advocated. Finally, this review article also summarizes the currently available literature for treatment of genuine catatonic symptoms. In conclusion, the abovementioned clinical syndromes must be rapidly recognized and treated. Early recognition and treatment of these movement disorders can under certain circumstances be lifesaving and favorably influence the later clinical outcome.