Long intergenic noncoding RNA 299 methylation in peripheral blood is a biomarker for triple-negative breast cancer

• Verfasst von: Lorenzo Bermejo, Justo [VerfasserIn]
• Verfasst von: Hamann, Ute [VerfasserIn]
• Verfasst von: Hoheisel, Jörg D. [VerfasserIn]
• Verfasst von: Garcia Mesa, Karen [VerfasserIn]
• Verfasst von: González Silos, Rosa [VerfasserIn]
• Titel: Long intergenic noncoding RNA 299 methylation in peripheral blood is a biomarker for triple-negative breast cancer
• Verf.angabe: Justo L Bermejo, Guanmengqian Huang, Mehdi Manoochehri, Karen G Mesa, Matthias Schick, Rosa G Silos, Yon-Dschun Ko, Thomas Brüning, Hiltrud Brauch, Wing-Yee Lo, Jörg D Hoheisel & Ute Hamann
• Jahr: 2019
• Umfang: 13 S.
• Fussnoten: Published online 13 September 2018 ; Gesehen am 19.07.2019
• Titel Quelle: Enthalten in: Epigenomics
• Ort Quelle: London [u.a.] : Taylor & Francis Group, 2009
• Jahr Quelle: 2019
• Band/Heft Quelle: 11(2019), 1, Seite 81-93
• ISSN Quelle: 1750-192X
• DOI: doi:10.2217/epi-2018-0121
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1669472612

Abstract

Aim: To identify DNA methylation biomarkers in peripheral blood samples from triple-negative breast cancer (TNBC) patients. Materials & methods: We conducted an epigenome-wide association study (EWAS): the most promising markers were identified in 233 TNBC case–control pairs (discovery set) and subsequently validated in an independent validation set (57 TNBC patients and 124 controls). Results: cg06588802 (LINC00299/ID2) showed a higher methylation in TNBC patients compared with controls (discovery set: 3% increase, p-value = 0.0009; validation set: 2% increase, p-value = 0.01). Consistent results at four neighboring methylation probes and the strong negative correlation (rho = -0.93) with LINC00299 expression add plausibility to this result. Conclusion: Hypermethylation of LINC00299 in peripheral blood may constitute a useful circulating biomarker for TNBC.