Endothelial cell fitness dictates the source of regenerating liver vasculature

• Verfasst von: Singhal, Mahak [VerfasserIn]
• Verfasst von: Liu, Xiaoting [VerfasserIn]
• Verfasst von: Inverso, Donato [VerfasserIn]
• Verfasst von: Jiang, Kai [VerfasserIn]
• Verfasst von: Dai, Jianing [VerfasserIn]
• Verfasst von: He, Hao [VerfasserIn]
• Verfasst von: Bartels, Susanne [VerfasserIn]
• Verfasst von: Li, Weiping [VerfasserIn]
• Verfasst von: Abdul Pari, Ashik Ahmed [VerfasserIn]
• Verfasst von: Gengenbacher, Nicolas [VerfasserIn]
• Verfasst von: Besemfelder, Eva [VerfasserIn]
• Verfasst von: Hui, Lijian [VerfasserIn]
• Verfasst von: Augustin, Hellmut [VerfasserIn]
• Verfasst von: Hu, Junhao [VerfasserIn]
• Titel: Endothelial cell fitness dictates the source of regenerating liver vasculature
• Verf.angabe: Mahak Singhal, Xiaoting Liu, Donato Inverso, Kai Jiang, Jianing Dai, Hao He, Susanne Bartels, Weiping Li, Ashik Ahmed Abdul Pari, Nicolas Gengenbacher, Eva Besemfelder, Lijian Hui, Hellmut G. Augustin, and Junhao Hu
• E-Jahr: 2018
• Jahr: 7 September, 2018
• Umfang: 12 S.
• Fussnoten: Gesehen am 16.10.2019
• Titel Quelle: Enthalten in: Journal of experimental medicine
• Ort Quelle: New York, NY : Rockefeller Univ. Press, 1896
• Jahr Quelle: 2018
• Band/Heft Quelle: 215(2018), 10, Seite 2497-2508
• ISSN Quelle: 1540-9538
• DOI: doi:10.1084/jem.20180008
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1678954861

Abstract

Graphical Abstract - <img class="fragment-image" alt="Figure1" src="http://jem.rupress.org/content/jem/215/10/2497/F1.medium.jpg" width="440" height="379"/>Download figureOpen in new tabDownload powerpoint - - Neoangiogenesis plays a key role in diverse pathophysiological conditions, including liver regeneration. Yet, the source of new endothelial cells (ECs) remains elusive. By analyzing the regeneration of the liver vasculature in irradiation-based myeloablative and nonmyeloablative bone marrow transplantation mouse models, we discovered that neoangiogenesis in livers with intact endothelium was solely mediated by proliferation of resident ECs. However, following irradiation-induced EC damage, bone marrow-derived mononuclear cells were recruited and incorporated into the vasculature. Further experiments with direct bone marrow infusion or granulocyte colony-stimulating factor (G-CSF)-mediated progenitor cell mobilization, which resembles clinically relevant stem cell therapy, demonstrated that bone marrow-derived cells did not contribute to the regeneration of liver vasculature after two-thirds partial hepatectomy (PHx). Taken together, the data reconcile many of the discrepancies in the literature and highlight that the cellular source of regenerating endothelium depends on the fitness of the residual vasculature.