Routine liver elastography could predict actuarial survival after liver transplantation

• Verfasst von: Pfeiffenberger, Jan [VerfasserIn]
• Verfasst von: Hornuß, Daniel [VerfasserIn]
• Verfasst von: Houben, Philipp [VerfasserIn]
• Verfasst von: Wehling, Cyrill [VerfasserIn]
• Verfasst von: Haken, Rebecca von [VerfasserIn]
• Verfasst von: Mieth, Markus [VerfasserIn]
• Verfasst von: Mehrabi, Arianeb [VerfasserIn]
• Verfasst von: Weiss, Karl Heinz [VerfasserIn]
• Verfasst von: Friedrich, Kilian [VerfasserIn]
• Titel: Routine liver elastography could predict actuarial survival after liver transplantation
• Verf.angabe: Jan Pfeiffenberger, Daniel Hornuss, Philip Houben, Cyrill Wehling, Rebecca von Haken, Vladimir Loszanowski, Markus Mieth, Arianeb Mehrabi, Karl-Heinz Weiss, Kilian Friedrich
• E-Jahr: 2019
• Jahr: 29 July 2019
• Umfang: 9 S.
• Fussnoten: Gesehen am 31.10.2019
• Titel Quelle: Enthalten in: Journal of gastrointestinal and liver diseases
• Ort Quelle: Cluj-Napoca : Soc., 2006
• Jahr Quelle: 2019
• Band/Heft Quelle: 28(2019), 3, Seite 271-277
• ISSN Quelle: 1842-1121
• DOI: doi:10.15403/jgld-218
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1680808893

Abstract

Background & Aims: Transient elastography (TE) has routinely been implemented in the diagnosis and assessment of chronic liver disease. Little data are available in the post liver transplant (LTx) setting. - Methods: Three months after LTx, we performed TE in 137 liver transplant recipients and investigated its predictive value upon further clinical outcome. The mean follow-up time for clinical outcome was 24 months. - Results: Mean TE value was 10.6 kPa (± 6.3 kPa; range 2.8 - 29.9 kPa). There was a significant correlation between TE and aspartate aminotransferase (AST) (p=0.004), gamma-glutamyl transferase (GGT) (p=0.031) and bilirubin (p<0.001) serum levels. In Cox univariate analysis, TE served as a predictor of actuarial survival free of liver transplantation (OR=1.111, 95%CI: 1.051-1.174; p<0.001). In multivariate analysis, TE remained an independent risk factor associated with reduced actuarial survival free of liver transplantation (OR=1.080, 95%CI: 1.001-1.166; p=0.047), along with thrombocytes (OR=0.992, 95%CI: 0.986-0.999; p=0.020) and metabolic co-disease (OR = 0.250, 95%CI: 0.070-0.895; p=0.033). - Conclusion: Transient elastography measurement at three months after LTx seems a robust predictor of survival in liver transplant recipients.