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Verfasst von:Jakob, Jens [VerfasserIn]   i
 Hohenberger, Peter [VerfasserIn]   i
Titel:Neoadjuvant therapy to downstage the extent of resection of gastrointestinal stromal tumors
Verf.angabe:Jens Jakob, Peter Hohenberger
E-Jahr:2018
Jahr:October 9, 2018
Umfang:7 S.
Fussnoten:Gesehen am 07.11.2019
Titel Quelle:Enthalten in: Visceral medicine
Ort Quelle:Basel : Karger, 2016
Jahr Quelle:2018
Band/Heft Quelle:34(2018), 5, Seite 359-365
ISSN Quelle:2297-475X
Abstract:<b><i>Introduction:</i></b> Gastrointestinal stromal tumors (GIST) are rare malignant tumors in terms of incidence, and they are not linked to specific symptoms. Often, primary tumors, particularly of the stomach, rectum, or rectovaginal space, are quite large when detected, and multivisceral resection seems to be the treatment of choice as the mainstay of therapy is complete tumor removal. If a gain-of-function mutation in the <i>KIT</i> gene is present, drug therapy with receptor tyrosine kinase inhibitors (RTKIs) might significantly downstage primary GIST tumors. <b><i>Methods:</i></b> A review of the literature was performed to identify the current evidence for preoperative treatment of GIST regarding toxicity, efficacy, and oncological outcome, including mutational data from our own database. <b><i>Results:</i></b> Four phase II as well as several cohort studies showed acceptable toxicity and no increased perioperative morbidity of preoperative imatinib. Progressive disease during preoperative treatment was a rare event, and partial response was achieved in 40-80% of all patients. For methodological reasons, the trials cannot prove an oncological long-term superiority of preoperative treatment. <b><i>Conclusion:</i></b> Preoperative therapy with imatinib is safe and recommended for patients with locally advanced GIST. Neoadjuvant imatinib therapy may enable less invasive and organ-sparing surgery, avoid tumor rupture during extensive resectional procedures, and improve the quality of perioperative RTKI treatment.
DOI:doi:10.1159/000493405
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1159/000493405
 Volltext: https://www.karger.com/Article/FullText/493405
 DOI: https://doi.org/10.1159/000493405
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1681396033
Verknüpfungen:→ Zeitschrift

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