| |  Online-Ressource |
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| Verfasst von: | Hirjak, Dusan [VerfasserIn]  |
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| | Meyer-Lindenberg, Andreas [VerfasserIn] |
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| | Kubera, Katharina Maria [VerfasserIn] |
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| | Thomann, Philipp [VerfasserIn] |
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| | Wolf, Robert Christian [VerfasserIn] |
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| Titel: | Motor dysfunction as research domain in the period preceding manifest schizophrenia |
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| Titelzusatz: | a systematic review |
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| Verf.angabe: | Dusan Hirjak, Andreas Meyer-Lindenberg, Katharina M. Kubera, Philipp A. Thomann, Robert C. Wolf |
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| E-Jahr: | 2018 |
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| Jahr: | 21 January 2018 |
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| Umfang: | 19 S. |
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| Fussnoten: | Accepted 21 January 2018 ; Gesehen am 27.01.2020 |
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| Titel Quelle: | Enthalten in: Neuroscience & biobehavioral reviews |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1978 |
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| Jahr Quelle: | 2018 |
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| Band/Heft Quelle: | 87(2018), Seite 87-105 |
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| ISSN Quelle: | 1873-7528 |
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| Abstract: | Schizophrenia is a severe behavioral syndrome of neurodevelopmental nature marked by primary or genuine motor abnormalities (GMA), which refer to spontaneous and medication-independent motor phenomena. Since motor dysfunction thus might be a consequence of events occurring during early childhood and adolescence, GMA can be detected in the period preceding manifest schizophrenia. However, the question whether motor system dysfunction might be a promising motor intermediate phenotype for schizophrenia remains unanswered. In this review, we systematically evaluate the evidence on GMA in healthy persons, individuals with schizotypal personality traits, persons at ultra-high risk for psychosis, and unaffected first-degree relatives of schizophrenia patients. What becomes evident is a continuum of GMA expression, which appears to be linked to abnormalities of cerebello-thalamo-cortical, fronto-parietal, and cortico-subcortical motor circuits. According to current evidence, motor dysfunction is a key aspect of the neurodevelopmental risk factor model of schizophrenia. Insights provided by this research will help promoting the RDoC Motor System construct and expand the clinical relevance of the motor domain in the period preceding manifest schizophrenia. |
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| DOI: | doi:10.1016/j.neubiorev.2018.01.011 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.neubiorev.2018.01.011 |
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| | Volltext: http://www.sciencedirect.com/science/article/pii/S0149763417308618 |
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| | DOI: https://doi.org/10.1016/j.neubiorev.2018.01.011 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | First-degree relatives |
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| | Genuine motor abnormalities |
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| | Intermediate phenotype |
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| | Schizophrenia |
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| | Schizotypy |
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| | UHR individuals |
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| K10plus-PPN: | 168854190X |
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| Verknüpfungen: | → Zeitschrift |
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Motor dysfunction as research domain in the period preceding manifest schizophrenia / Hirjak, Dusan [VerfasserIn]; 21 January 2018 (Online-Ressource)
