| |  Online-Ressource |
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| Verfasst von: | Patel, Parthive H. [VerfasserIn]  |
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| | Pénalva, Clothilde [VerfasserIn] |
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| | Kardorff, Michael [VerfasserIn] |
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| | Roca, Marianne [VerfasserIn] |
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| | Pavlović, Bojana [VerfasserIn] |
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| | Thiel, Anja [VerfasserIn] |
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| | Teleman, Aurelio A. [VerfasserIn] |
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| | Edgar, Bruce [VerfasserIn] |
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| Titel: | Damage sensing by a Nox-Ask1-MKK3-p38 signaling pathway mediates regeneration in the adult Drosophila midgut |
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| Verf.angabe: | Parthive H. Patel, Clothilde Pénalva, Michael Kardorff, Marianne Roca, Bojana Pavlović, Anja Thiel, Aurelio A. Teleman & Bruce A. Edgar |
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| E-Jahr: | 2019 |
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| Jahr: | 25 September 2019 |
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| Umfang: | 14 S. |
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| Fussnoten: | Gesehen am 04.02.2020 |
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| Titel Quelle: | Enthalten in: Nature Communications |
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| Ort Quelle: | [London] : Nature Publishing Group UK, 2010 |
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| Jahr Quelle: | 2019 |
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| Band/Heft Quelle: | 10(2019) Artikel-Nummer 4365, 14 Seiten |
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| ISSN Quelle: | 2041-1723 |
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| Abstract: | Epithelia are exposed to diverse types of stress and damage from pathogens and the environment, and respond by regenerating. Yet, the proximal mechanisms that sense epithelial damage remain poorly understood. Here we report that p38 signaling is activated in adult Drosophila midgut enterocytes in response to diverse stresses including pathogenic bacterial infection and chemical and mechanical insult. Two upstream kinases, Ask1 and Licorne (MKK3), are required for p38 activation following infection, oxidative stress, detergent exposure and wounding. Ask1-p38 signaling in enterocytes is required upon infection to promote full intestinal stem cell (ISC) activation and regeneration, partly through Upd3/Jak-Stat signaling. Furthermore, reactive oxygen species (ROS) produced by the NADPH oxidase Nox in enterocytes, are required for p38 activation in enterocytes following infection or wounding, and for ISC activation upon infection or detergent exposure. We propose that Nox-ROS-Ask1-MKK3-p38 signaling in enterocytes integrates multiple different stresses to induce regeneration. |
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| DOI: | doi:10.1038/s41467-019-12336-w |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: http://dx.doi.org/10.1038/s41467-019-12336-w |
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| | DOI: https://doi.org/10.1038/s41467-019-12336-w |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Animals |
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| | Animals, Genetically Modified |
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| | Bacterial Infections |
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| | Drosophila melanogaster |
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| | Drosophila Proteins |
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| | Enterocytes |
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| | Intestinal Mucosa |
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| | Intestines |
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| | MAP Kinase Kinase 3 |
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| | MAP Kinase Kinase Kinases |
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| | NADPH Oxidases |
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| | Oxidative Stress |
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| | p38 Mitogen-Activated Protein Kinases |
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| | Regeneration |
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| | Signal Transduction |
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| | Stem Cells |
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| | Stress, Mechanical |
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| K10plus-PPN: | 1689205911 |
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| Verknüpfungen: | → Zeitschrift |
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Damage sensing by a Nox-Ask1-MKK3-p38 signaling pathway mediates regeneration in the adult Drosophila midgut / Patel, Parthive H. [VerfasserIn]; 25 September 2019 (Online-Ressource)
