| |  Online-Ressource |
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| Verfasst von: | Kim, Don-Kyu [VerfasserIn]  |
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| | Feng, Rilu [VerfasserIn] |
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| | Dooley, Steven [VerfasserIn] |
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| Titel: | Estrogen-related receptor γ controls sterol regulatory element-binding protein-1c expression and alcoholic fatty liver |
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| Verf.angabe: | Don-Kyu Kim, Yong-Hoon Kim, Jae-Ho Lee, Yoon Seok Jung, Jina Kim, Rilu Feng, Tae-Il Jeon, In-Kyu Lee, Sung Jin Cho, Seung-Soon Im, Steven Dooley, Timothy F. Osborne, Chul-Ho Lee, Hueng-Sik Choi |
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| E-Jahr: | 2019 |
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| Jahr: | December 2019 |
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| Umfang: | 9 S. |
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| Fussnoten: | Gesehen am 19.02.2020 |
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| Titel Quelle: | Enthalten in: Biochimica et biophysica acta. Molecular and cell biology of lipids |
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| Ort Quelle: | Amsterdam : Elsevier, 1998 |
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| Jahr Quelle: | 2019 |
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| Band/Heft Quelle: | 1864(2019,12) Artikel-Nummer 158521, 9 Seiten |
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| ISSN Quelle: | 1879-2618 |
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| Abstract: | Although SREBP-1c regulates key enzymes required for hepatic de novo lipogenesis, the mechanisms underlying transcriptional regulation of SREBP-1c in pathogenesis of alcoholic fatty liver is still incompletely understood. In this study, we investigated the role of ERRγ in alcohol-mediated hepatic lipogenesis and examined the possibility to ameliorate alcoholic fatty liver through its inverse agonist. Hepatic ERRγ and SREBP-1c expression was increased by alcohol-mediated activation of CB1 receptor signaling. Deletion and mutation analyses of the Srebp-1c gene promoter showed that ERRγ directly regulates Srebp-1c gene transcription via binding to an ERR-response element. Overexpression of ERRγ significantly induced SREBP-1c expression and fat accumulation in liver of mice, which were blocked in Srebp-1c-knockout hepatocytes. Conversely, liver-specific ablation of ERRγ gene expression attenuated alcohol-mediated induction of SREBP-1c expression. Finally, an ERRγ inverse agonist, GSK5182, significantly ameliorates fatty liver disease in chronically alcohol-fed mice through inhibition of SREBP-1c-mediated fat accumulation. ERRγ mediates alcohol-induced hepatic lipogenesis by upregulating SREBP-1c expression, which can be blunted by the inverse agonist for ERRγ, which may be an attractive therapeutic strategy for the treatment of alcoholic fatty liver disease in human. |
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| DOI: | doi:10.1016/j.bbalip.2019.158521 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.bbalip.2019.158521 |
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| | Verlag: http://www.sciencedirect.com/science/article/pii/S1388198119301714 |
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| | DOI: https://doi.org/10.1016/j.bbalip.2019.158521 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Alcoholic fatty liver |
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| | CB receptor |
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| | ERRγ |
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| | Gene regulation |
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| | Hepatic lipogenesis |
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| | SREBP-1c |
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| K10plus-PPN: | 1690391669 |
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| Verknüpfungen: | → Zeitschrift |
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Estrogen-related receptor γ controls sterol regulatory element-binding protein-1c expression and alcoholic fatty liver / Kim, Don-Kyu [VerfasserIn]; December 2019 (Online-Ressource)
