Obsessive-compulsive symptoms in psychotic disorders

• Verfasst von: Schirmbeck, Frederike [VerfasserIn]
• Verfasst von: Konijn, Max [VerfasserIn]
• Verfasst von: Hoetjes, Vera [VerfasserIn]
• Verfasst von: Zink, Mathias [VerfasserIn]
• Verfasst von: de Haan, Lieuwe [VerfasserIn]
• Titel: Obsessive-compulsive symptoms in psychotic disorders
• Titelzusatz: longitudinal associations of symptom clusters on between- and within-subject levels
• Verf.angabe: Frederike Schirmbeck, Max Konijn, Vera Hoetjes, Mathias Zink, Lieuwe de Haan, For Genetic Risk and Outcome of Psychosis (GROUP)
• E-Jahr: 2019
• Jahr: 8 March 2018
• Jahr des Originals: 2018
• Umfang: 11 S.
• Fussnoten: Published online: 8 March 2018 ; Gesehen am 17.03.2020
• Titel Quelle: Enthalten in: European archives of psychiatry and clinical neuroscience
• Ort Quelle: Darmstadt : Steinkopff, 1868
• Jahr Quelle: 2019
• Band/Heft Quelle: 269(2019), 2, Seite 245-255
• ISSN Quelle: 1433-8491
• DOI: doi:10.1007/s00406-018-0884-4
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1692696068

Abstract

Obsessive-compulsive symptoms (OCS) are frequently reported in patients with schizophrenia and have been associated with subjective distress and higher impairment. Recent studies suggest fluctuation in co-occurring OCS and associations with the course of psychotic symptoms. Current evidence is limited by few studies with long assessments intervals and a sole focus on between-subject comparisons. The aim of this study was to specifically investigate co-variation of symptom domains over time within individuals. Patients with a psychotic disorder (n = 56) and un-affected siblings (n = 49) completed monthly assessments of clinical and subclinical symptoms over 6 months. Mixed-model multilevel analyses examined the variability and relationship between OCS and positive, negative, and depressive symptoms on the between- and within-subject level. Symptom domains were associated across subjects and assessment times, in patients and siblings, with the strongest association between OCS and (subclinical) positive symptoms. Within-subjects, substantial variability and co-variation of all symptom domains was found. Particularly, between-subject differences in positive symptoms and within-subject change in depressive symptoms predicted subsequent OCS in patients 1 months later. This is the first prospective study disaggregating between and within-subject associations between co-occurring OCS and symptom cluster of psychosis. Differences on these two levels suggest different underlying mechanisms. The association between depressive symptoms and subsequent increase/decrease of OCS within patients may have important treatment implications.