Status: Bibliographieeintrag
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| Verfasst von: | Kuchen, Erika [VerfasserIn]  |
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| | Becker, Nils B. [VerfasserIn] |
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| | Claudino, Nina [VerfasserIn] |
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| | Höfer, Thomas [VerfasserIn] |
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| Titel: | Hidden long-range memories of growth and cycle speed correlate cell cycles in lineage trees |
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| Verf.angabe: | Erika E. Kuchen, Nils B. Becker, Nina Claudino, Thomas Höfer |
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| E-Jahr: | 2020 |
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| Jahr: | Jan 23, 2020 |
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| Umfang: | ?$p9 (2020) Artikel-Nummer e51002 S. |
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| Fussnoten: | Gesehen am 26.03.2020 |
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| Titel Quelle: | Enthalten in: eLife |
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| Ort Quelle: | Cambridge : eLife Sciences Publications, 2012 |
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| Jahr Quelle: | 2020 |
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| Band/Heft Quelle: | 9(2020) |
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| ISSN Quelle: | 2050-084X |
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| Abstract: | Cell heterogeneity may be caused by stochastic or deterministic effects. The inheritance of regulators through cell division is a key deterministic force, but identifying inheritance effects in a systematic manner has been challenging. Here, we measure and analyze cell cycles in deep lineage trees of human cancer cells and mouse embryonic stem cells and develop a statistical framework to infer underlying rules of inheritance. The observed long-range intra-generational correlations in cell-cycle duration, up to second cousins, seem paradoxical because ancestral correlations decay rapidly. However, this correlation pattern is naturally explained by the inheritance of both cell size and cell-cycle speed over several generations, provided that cell growth and division are coupled through a minimum-size checkpoint. This model correctly predicts the effects of inhibiting cell growth or cycle progression. In sum, we show how fluctuations of cell cycles across lineage trees help in understanding the coordination of cell growth and division. |
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| DOI: | doi:10.7554/eLife.51002 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.7554/eLife.51002 |
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| | DOI: https://doi.org/10.7554/eLife.51002 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | cell cycle |
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| | cell growth |
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| | cell lineages |
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| | cellular memory |
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| | Hidden-Markov model |
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| | size checkpoint |
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| K10plus-PPN: | 1693372606 |
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| Verknüpfungen: | → Zeitschrift |
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Hidden long-range memories of growth and cycle speed correlate cell cycles in lineage trees / Kuchen, Erika [VerfasserIn]; Jan 23, 2020 (Online-Ressource)
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