The actin cytoskeleton as an active adaptive material

• Verfasst von: Banerjee, Shiladitya [VerfasserIn]
• Verfasst von: Gardel, Margaret L. [VerfasserIn]
• Verfasst von: Schwarz, Ulrich S. [VerfasserIn]
• Titel: The actin cytoskeleton as an active adaptive material
• Verf.angabe: Shiladitya Banerjee, Margaret L. Gardel, and Ulrich S. Schwarz
• E-Jahr: 2020
• Jahr: [2020]
• Umfang: 19 S.
• Fussnoten: Gesehen am 14.04.2020
• Titel Quelle: Enthalten in: Annual review of condensed matter physics
• Ort Quelle: Palo Alto, Calif. : Annual Reviews, 2010
• Jahr Quelle: 2020
• Band/Heft Quelle: 11(2020), 1, Seite 421-439
• ISSN Quelle: 1947-5462
• DOI: doi:10.1146/annurev-conmatphys-031218-013231
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1694465748

Abstract

Actin is the main protein used by biological cells to adapt their structure and mechanics to their needs. Cellular adaptation is made possible by molecular processes that strongly depend on mechanics. The actin cytoskeleton is also an active material that continuously consumes energy. This allows for dynamical processes that are possible only out of equilibrium and opens up the possibility for multiple layers of control that have evolved around this single protein. Here we discuss the actin cytoskeleton from the viewpoint of physics as an active adaptive material that can build structures superior to man-made soft matter systems. Not only can actin be used to build different network architectures on demand and in an adaptive manner, but it also exhibits the dynamical properties of feedback systems, like excitability, bistability, or oscillations. Therefore, it is a prime example of how biology couples physical structure and information flow and a role model for biology-inspired metamaterials.