Prognostic relevance of programmed death-ligand 1 expression and microsatellite status in small bowel adenocarcinoma

• Verfasst von: Klose, Johannes [VerfasserIn]
• Verfasst von: Lasitschka, Felix [VerfasserIn]
• Verfasst von: Horsch, Cornelia [VerfasserIn]
• Verfasst von: Strowitzki, Moritz [VerfasserIn]
• Verfasst von: Bruckner, Thomas [VerfasserIn]
• Verfasst von: Volz, Claudia [VerfasserIn]
• Verfasst von: Schmidt, Thomas [VerfasserIn]
• Verfasst von: Schneider, Martin [VerfasserIn]
• Titel: Prognostic relevance of programmed death-ligand 1 expression and microsatellite status in small bowel adenocarcinoma
• Verf.angabe: Johannes Klose, Felix Lasitschka, Cornelia Horsch, Moritz J. Strowitzki, Thomas Bruckner, Claudia Volz, Thomas Schmidt, Martin Schneider
• E-Jahr: 2020
• Jahr: 19 Mar 2020
• Umfang: 9 S.
• Fussnoten: Gesehen am 17.04.2020
• Titel Quelle: Enthalten in: Scandinavian journal of gastroenterology
• Ort Quelle: Abingdon : Taylor & Francis Group, 1966
• Jahr Quelle: 2020
• Band/Heft Quelle: 55(2020), 3, Seite 321-329
• ISSN Quelle: 1502-7708
• DOI: doi:10.1080/00365521.2020.1734073
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: microsatellite status
• Sach-SW: outcome
• Sach-SW: prognosis
• Sach-SW: programmed death ligand 1 pathway
• Sach-SW: Small bowel adenocarcinoma
• K10plus-PPN: 1694842428

Abstract

Background: Small bowel adenocarcinoma (SBA) is a dreadful disease. Patient prognosis is limited due to late presentation and ineffective chemotherapy. PD-1/PD-L1 checkpoint immunotherapy is regarded as a promising approach in several cancer entities. The association of PD-1/PD-L1 expression and its impact on patient prognosis with SBA is unclear. Material and methods: Seventy-five consecutive patients who underwent surgery for SBA were retrospectively analyzed and stained for PD-L1 expression in the tumour or the stroma. Analysis of mismatch repair genes was performed to determine microsatellite status. Kaplan-Meier estimate was used to analyze patient survival. Univariate and multivariable Cox regression-analyses were used to assess the impact of PD-L1 expression and microsatellite status on patient survival.Results: PD-L1 was weakly upregulated within the tumour or the stroma and associated with prolonged survival (p = .0071 and p = .0472, respectively). Fifty-one tumours (68%) revealed microsatellite stability (MSS) and 24 tumours (32%) were microsatellite instable (MSI) without correlating with patient survival (p = .611). Neither PD-L1 expression in the tumour nor in the stroma was identified as an independent risk factor influencing survival (p = .572 and p = .3055).Conclusion: Although PD-L1 expression is associated with prolonged survival, it was not identified as an independent prognostic marker. Microsatellite status did not influence long-term survival.