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| Verfasst von: | Millenet, Sabina [VerfasserIn]  |
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| | Nees, Frauke [VerfasserIn] |
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| | Heintz, Stefan [VerfasserIn] |
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| | Bach, Christiane [VerfasserIn] |
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| | Frank, Josef [VerfasserIn] |
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| | Vollstädt-Klein, Sabine [VerfasserIn] |
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| | Bokde, Arun [VerfasserIn] |
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| | Bromberg, Uli [VerfasserIn] |
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| | Büchel, Christian [VerfasserIn] |
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| | Quinlan, Erin B. [VerfasserIn] |
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| | Desrivières, Sylvane [VerfasserIn] |
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| | Fröhner, Juliane [VerfasserIn] |
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| | Flor, Herta [VerfasserIn] |
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| | Frouin, Vincent [VerfasserIn] |
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| | Garavan, Hugh [VerfasserIn] |
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| | Gowland, Penny [VerfasserIn] |
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| | Heinz, Andreas [VerfasserIn] |
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| | Ittermann, Bernd [VerfasserIn] |
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| | Lemaire, Herve [VerfasserIn] |
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| | Martinot, Jean-Luc [VerfasserIn] |
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| | Martinot, Marie-Laure P. [VerfasserIn] |
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| | Papadoulos, Dimitri O. [VerfasserIn] |
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| | Paus, Tomáš [VerfasserIn] |
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| | Poustka, Luise [VerfasserIn] |
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| | Rietschel, Marcella [VerfasserIn] |
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| | Smolka, Michael [VerfasserIn] |
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| | Walter, Henrik [VerfasserIn] |
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| | Whelan, Rob [VerfasserIn] |
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| | Schumann, Gunter [VerfasserIn] |
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| | Banaschewski, Tobias [VerfasserIn] |
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| | Hohmann, Sarah [VerfasserIn] |
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| Titel: | COMT Val158Met polymorphism and social impairment interactively affect attention-deficit hyperactivity symptoms in healthy adolescents |
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| Verf.angabe: | Sabina K. Millenet, Frauke Nees, Stefan Heintz, Christiane Bach, Josef Frank, Sabine Vollstädt-Klein, Arun Bokde, Uli Bromberg, Christian Büchel, Erin B. Quinlan, Sylvane Desrivières, Juliane Fröhner, Herta Flor, Vincent Frouin, Hugh Garavan, Penny Gowland, Andreas Heinz, Bernd Ittermann, Herve Lemaire, Jean-Luc Martinot, Marie-Laure P. Martinot, Dimitri O. Papadoulos, Tomáš Paus, Luise Poustka, Marcella Rietschel, Michael N. Smolka, Henrik Walter, Rob Whelan, Gunter Schumann, Tobias Banaschewski and Sarah Hohmann on behalf of the IMAGEN Consortium |
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| E-Jahr: | 2018 |
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| Jahr: | 31 July 2018 |
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| Umfang: | 8 S. |
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| Fussnoten: | Gesehen am 20.04.2020 |
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| Titel Quelle: | Enthalten in: Frontiers in genetics |
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| Ort Quelle: | Lausanne : Frontiers Media, 2010 |
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| Jahr Quelle: | 2018 |
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| Band/Heft Quelle: | 9(2018) Artikel-Nummer 284, 8 Seiten |
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| ISSN Quelle: | 1664-8021 |
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| Abstract: | The dopaminergic system has been shown to have substantial effects on the etiology of attention-deficit hyperactivity disorder (ADHD). However, while some studies found a significant direct effect, others did not. In this context, social behavior might play an important role as a factor that is related both to the dopaminergic system and ADHD. In a large epidemiological sample of adolescents (N = 462; 16-17 years), we assessed the level of ADHD symptoms using the Strengths and Difficulties Questionnaire, social behavior using the Social Responsiveness Scale, and the allelic distribution of the dopaminergic catechol-O-methyltransferase (COMT) Val158Met polymorphism. We found a significant association between COMT and social impairment, insofar as Met-allele carriers showed increased levels of social impairment. Moreover, social impairment significantly determined an association between COMT and ADHD (explained variance: 19.09%). This effect did not significantly differ between males and females. COMT and social impairment might interactively affect ADHD symptomatology, and could thus represent significant gene-phenotypic risk factors for ADHD symptomatology. This might have interesting implications for prevention and intervention strategies with a focus on social behavior in genetically at-risk individuals. |
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| DOI: | doi:10.3389/fgene.2018.00284 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.3389/fgene.2018.00284 |
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| | DOI: https://doi.org/10.3389/fgene.2018.00284 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | ADHD |
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| | adolescence |
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| | COMT |
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| | moderation |
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| | social impairment |
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| K10plus-PPN: | 1694961222 |
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| Verknüpfungen: | → Zeitschrift |
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COMT Val158Met polymorphism and social impairment interactively affect attention-deficit hyperactivity symptoms in healthy adolescents / Millenet, Sabina [VerfasserIn]; 31 July 2018 (Online-Ressource)
