Voltage-gated and stretch-activated potassium channels in the human heart

• Verfasst von: Schmidt, Constanze [VerfasserIn]
• Verfasst von: Peyronnet, Remi [VerfasserIn]
• Titel: Voltage-gated and stretch-activated potassium channels in the human heart
• Verf.angabe: Constanze Schmidt & Rémi Peyronnet
• E-Jahr: 2018
• Jahr: 5 January 2018
• Umfang: 7 S.
• Fussnoten: Gesehen am 21.04.2020
• Titel Quelle: Enthalten in: Herzschrittmachertherapie & Elektrophysiologie
• Ort Quelle: Darmstadt : Steinkopff, 1997
• Jahr Quelle: 2018
• Band/Heft Quelle: 29(2018), 1, Seite 36-42
• ISSN Quelle: 1435-1544
• DOI: doi:10.1007/s00399-017-0541-z
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1695555473

Abstract

Ion channels are essential for electrical signaling and contractility in cardiomyocytes. Detailed knowledge about the molecular function and regulation of cardiac ion channels is crucial for understanding cardiac physiology and pathophysiology especially in the field of arrhythmias. This review aims at providing a general overview on the identity, functional characteristics, and roles of voltage-gated as well as stretch-activated potassium selective channels in the heart. In particular, we will highlight potential therapeutic targets as well as the emerging fields of future investigations.