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| Verfasst von: | André, Viola [VerfasserIn]  |
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| | Gau, Christine [VerfasserIn] |
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| | Scheideler, Angelika [VerfasserIn] |
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| | Aguilar-Pimentel, Juan A. [VerfasserIn] |
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| | Amarie, Oana V. [VerfasserIn] |
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| | Becker, Lore [VerfasserIn] |
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| | Garrett, Lillian [VerfasserIn] |
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| | Hans, Wolfgang [VerfasserIn] |
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| | Hölter-Koch, Sabine [VerfasserIn] |
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| | Janik, Dirk [VerfasserIn] |
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| | Moreth, Kristin [VerfasserIn] |
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| | Neff, Frauke [VerfasserIn] |
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| | Östereicher, Manuela [VerfasserIn] |
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| | Racz, Ildiko [VerfasserIn] |
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| | Rathkolb, Birgit [VerfasserIn] |
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| | Rozman, Jan [VerfasserIn] |
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| | Bekeredjian, Raffi [VerfasserIn] |
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| | Graw, Jochen [VerfasserIn] |
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| | Klingenspor, Martin [VerfasserIn] |
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| | Klopstock, Thomas [VerfasserIn] |
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| | Ollert, Markus [VerfasserIn] |
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| | Schmidt-Weber, Carsten [VerfasserIn] |
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| | Wolf, Eckhard [VerfasserIn] |
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| | Wurst, Wolfgang [VerfasserIn] |
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| | Gailus-Durner, Valérie [VerfasserIn] |
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| | Brielmeier, Markus [VerfasserIn] |
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| | Fuchs, Helmut [VerfasserIn] |
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| | Angelis, Martin Hrabé de [VerfasserIn] |
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| Titel: | Laboratory mouse housing conditions can be improved using common environmental enrichment without compromising data |
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| Verf.angabe: | Viola André, Christine Gau, Angelika Scheideler, Juan A. Aguilar-Pimentel, Oana V. Amarie, Lore Becker, Lillian Garrett, Wolfgang Hans, Sabine M. Hölter, Dirk Janik, Kristin Moreth, Frauke Neff, Manuela Östereicher, Ildiko Racz, Birgit Rathkolb, Jan Rozman, Raffi Bekeredjian, Jochen Graw, Martin Klingenspor, Thomas Klopstock, Markus Ollert, Carsten Schmidt-Weber, Eckhard Wolf, Wolfgang Wurst, Valérie Gailus-Durner, Markus Brielmeier, Helmut Fuchs, Martin Hrabé de Angelis |
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| E-Jahr: | 2018 |
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| Jahr: | April 16, 2018 |
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| Umfang: | 24 S. |
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| Fussnoten: | Gesehen am 25.05.2020 |
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| Titel Quelle: | Enthalten in: Public Library of SciencePLoS biology |
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| Ort Quelle: | Lawrence, KS : PLoS, 2003 |
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| Jahr Quelle: | 2018 |
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| Band/Heft Quelle: | 16(2018,4) Artikel-Nummer e2005019, 24 Seiten |
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| ISSN Quelle: | 1545-7885 |
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| Abstract: | Animal welfare requires the adequate housing of animals to ensure health and well-being. The application of environmental enrichment is a way to improve the well-being of laboratory animals. However, it is important to know whether these enrichment items can be incorporated in experimental mouse husbandry without creating a divide between past and future experimental results. Previous small-scale studies have been inconsistent throughout the literature, and it is not yet completely understood whether and how enrichment might endanger comparability of results of scientific experiments. Here, we measured the effect on means and variability of 164 physiological parameters in 3 conditions: with nesting material with or without a shelter, comparing these 2 conditions to a “barren” regime without any enrichments. We studied a total of 360 mice from each of 2 mouse strains (C57BL/6NTac and DBA/2NCrl) and both sexes for each of the 3 conditions. Our study indicates that enrichment affects the mean values of some of the 164 parameters with no consistent effects on variability. However, the influence of enrichment appears negligible compared to the effects of other influencing factors. Therefore, nesting material and shelters may be used to improve animal welfare without impairment of experimental outcome or loss of comparability to previous data collected under barren housing conditions. |
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| DOI: | doi:10.1371/journal.pbio.2005019 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1371/journal.pbio.2005019 |
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| | Volltext: https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.2005019 |
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| | DOI: https://doi.org/10.1371/journal.pbio.2005019 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Animal behavior |
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| | Animal welfare |
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| | Body weight |
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| | Clinical chemistry |
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| | Eyes |
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| | Laboratory animals |
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| | Mice |
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| | Physiological parameters |
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| K10plus-PPN: | 1698758081 |
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| Verknüpfungen: | → Zeitschrift |
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Laboratory mouse housing conditions can be improved using common environmental enrichment without compromising data / André, Viola [VerfasserIn]; April 16, 2018 (Online-Ressource)
