Status: Bibliographieeintrag
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| Verfasst von: | Ven, Gido M. [VerfasserIn]  |
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| | Trouche, Stéphanie [VerfasserIn] |
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| | McNamara, Colin G. [VerfasserIn] |
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| | Allen, Kevin [VerfasserIn] |
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| | Dupret, David [VerfasserIn] |
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| Titel: | Hippocampal offline reactivation consolidates recently formed cell assembly patterns during sharp wave-ripples |
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| Verf.angabe: | Gido M. van de Ven, Stéphanie Trouche, Colin G. McNamara, Kevin Allen, David Dupret |
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| E-Jahr: | 2016 |
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| Jahr: | [December 7, 2016] |
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| Umfang: | 7 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Gesehen am 29.05.2020 |
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| Titel Quelle: | Enthalten in: Neuron |
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| Ort Quelle: | [Cambridge, Mass.] : Cell Press, 1988 |
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| Jahr Quelle: | 2016 |
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| Band/Heft Quelle: | 92(2016), 5, Seite 968-974 |
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| ISSN Quelle: | 1097-4199 |
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| Abstract: | The ability to reinstate neuronal assemblies representing mnemonic information is thought to require their consolidation through offline reactivation during sleep/rest. To test this, we detected cell assembly patterns formed by repeated neuronal co-activations in the mouse hippocampus during exploration of spatial environments. We found that the reinstatement of assembly patterns representing a novel, but not a familiar, environment correlated with their offline reactivation and was impaired by closed-loop optogenetic disruption of sharp wave-ripple oscillations. Moreover, we discovered that reactivation was only required for the reinstatement of assembly patterns whose expression was gradually strengthened during encoding of a novel place. The context-dependent reinstatement of assembly patterns whose expression did not gain in strength beyond the first few minutes of spatial encoding was not dependent on reactivation. This demonstrates that the hippocampus can hold concurrent representations of space that markedly differ in their encoding dynamics and their dependence on offline reactivation for consolidation. - Video Abstract |
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| DOI: | doi:10.1016/j.neuron.2016.10.020 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/j.neuron.2016.10.020 |
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| | Volltext: http://www.sciencedirect.com/science/article/pii/S0896627316307218 |
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| | DOI: https://doi.org/10.1016/j.neuron.2016.10.020 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1699065004 |
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| Verknüpfungen: | → Zeitschrift |
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Hippocampal offline reactivation consolidates recently formed cell assembly patterns during sharp wave-ripples / Ven, Gido M. [VerfasserIn]; [December 7, 2016] (Online-Ressource)
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