The dynamic pattern of recurrence in curatively resected non-small cell lung cancer patients

• Verfasst von: Yamauchi, Yoshikane [VerfasserIn]
• Verfasst von: Muley, Thomas [VerfasserIn]
• Verfasst von: Safi, Seyer [VerfasserIn]
• Verfasst von: Rieken, Stefan [VerfasserIn]
• Verfasst von: Bischoff, Helge [VerfasserIn]
• Verfasst von: Kappes, Jutta [VerfasserIn]
• Verfasst von: Warth, Arne [VerfasserIn]
• Verfasst von: Herth, Felix [VerfasserIn]
• Verfasst von: Dienemann, Hendrik [VerfasserIn]
• Verfasst von: Hoffmann, Hans [VerfasserIn]
• Titel: The dynamic pattern of recurrence in curatively resected non-small cell lung cancer patients
• Titelzusatz: experiences at a single institution
• Verf.angabe: Yoshikane Yamauchi, Thomas Muley, Seyer Safi, Stefan Rieken, Helge Bischoff, Jutta Kappes, Arne Warth, Felix J. F. Herth, Hendrik Dienemann, Hans Hoffmann
• E-Jahr: 2015
• Jahr: 15 September 2015
• Umfang: 6 S.
• Fussnoten: Gesehen am 09.07.2020
• Titel Quelle: Enthalten in: Lung cancer
• Ort Quelle: Amsterdam [u.a.] : Elsevier, 1985
• Jahr Quelle: 2015
• Band/Heft Quelle: 90(2015), 2, Seite 224-229
• ISSN Quelle: 1872-8332
• DOI: doi:10.1016/j.lungcan.2015.09.010
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Hazard function
• Sach-SW: Non-small cell lung cancer
• Sach-SW: Recurrence
• K10plus-PPN: 1724142569

Abstract

Purpose - To investigate the hazard function of tumor recurrence in patients with completely (R0) resected non-small cell lung cancer. - Methods - A total of 1374 patients treated between 2003 and 2009 with complete resection and systematic lymph node dissection were studied. The risk of recurrence at a given time after operation was studied utilizing the cause-specific hazard function. Recurrence was categorized as local recurrence or distant recurrence. The risk distribution was assessed using clinical and pathological factors. - Results - The hazard function for recurrence presented an early peak at approximately 10 months after surgery and maintained a tapered plateau-like tail extending up to 8 years. A similar risk pattern was detected for both local recurrence and distant recurrence, while the risk of distant recurrence was higher than that of local recurrence. The double-peaked pattern of hazard rate was present in several subgroups, such as p-stage IA patients. A comparison of histology and status of nodal involvement showed that pN1-2 adenocarcinoma patients demonstrated a high hazard rate of distant recurrence and that pN0 adenocarcinoma patients exhibited a small recurrent risk for a longer time. Squamous cell carcinoma patients showed only little difference in risk. - Conclusions - The data may be useful to select patients at high risk of recurrence and may provide information for each patient to decide how to manage the postoperative follow-up individually.