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| Verfasst von: | Mille, Frédéric [VerfasserIn]  |
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| | Tamayo-Orrego, Lukas [VerfasserIn] |
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| | Lévesque, Martin [VerfasserIn] |
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| | Remke, Marc [VerfasserIn] |
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| | Korshunov, Andrey [VerfasserIn] |
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| | Cardin, Julie [VerfasserIn] |
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| | Bouchard, Nicolas [VerfasserIn] |
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| | Izzi, Luisa [VerfasserIn] |
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| | Kool, Marcel [VerfasserIn] |
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| | Northcott, Paul A. [VerfasserIn] |
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| | Taylor, Michael D. [VerfasserIn] |
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| | Pfister, Stefan [VerfasserIn] |
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| | Charron, Frédéric [VerfasserIn] |
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| Titel: | The Shh receptor Boc promotes progression of early medulloblastoma to advanced tumors |
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| Verf.angabe: | Frédéric Mille, Lukas Tamayo-Orrego, Martin Lévesque, Marc Remke, Andrey Korshunov, Julie Cardin, Nicolas Bouchard, Luisa Izzi, Marcel Kool, Paul A. Northcott, Michael D. Taylor, Stefan M. Pfister, and Frédéric Charron |
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| E-Jahr: | 2014 |
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| Jahr: | September 25, 2014 |
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| Umfang: | 14 S. |
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| Fussnoten: | Gesehen am 13.07.2020 |
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| Titel Quelle: | Enthalten in: Developmental cell |
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| Ort Quelle: | Cambridge, Mass. : Cell Press, 2001 |
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| Jahr Quelle: | 2014 |
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| Band/Heft Quelle: | 31(2014), 1, Seite 34-47 |
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| ISSN Quelle: | 1878-1551 |
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| Abstract: | During cerebellar development, Sonic hedgehog (Shh) signaling drives the proliferation of granule cell precursors (GCPs). Aberrant activation of Shh signaling causes overproliferation of GCPs, leading to medulloblastoma. Although the Shh-binding protein Boc associates with the Shh receptor Ptch1 to mediate Shh signaling, whether Boc plays a role in medulloblastoma is unknown. Here, we show that BOC is upregulated in medulloblastomas and induces GCP proliferation. Conversely, Boc inactivation reduces proliferation and progression of early medulloblastomas to advanced tumors. Mechanistically, we find that Boc, through elevated Shh signaling, promotes high levels of DNA damage, an effect mediated by CyclinD1. High DNA damage in the presence of Boc increases the incidence of Ptch1 loss of heterozygosity, an important event in the progression from early to advanced medulloblastoma. Together, our results indicate that DNA damage promoted by Boc leads to the demise of its own coreceptor, Ptch1, and consequently medulloblastoma progression. |
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| DOI: | doi:10.1016/j.devcel.2014.08.010 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/j.devcel.2014.08.010 |
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| | Volltext: http://www.sciencedirect.com/science/article/pii/S1534580714005206 |
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| | DOI: https://doi.org/10.1016/j.devcel.2014.08.010 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1724477196 |
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| Verknüpfungen: | → Zeitschrift |
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¬The¬ Shh receptor Boc promotes progression of early medulloblastoma to advanced tumors / Mille, Frédéric [VerfasserIn]; September 25, 2014 (Online-Ressource)
