| |  Online-Ressource |
|---|
| Verfasst von: | Chen, Jeremy Tsung-Chieh [VerfasserIn]  |
|---|
| | Guo, Da [VerfasserIn] |
|---|
| | Campanelli, Dario [VerfasserIn] |
|---|
| | Frattini, Flavia [VerfasserIn] |
|---|
| | Mayer, Florian [VerfasserIn] |
|---|
| | Zhou, Luming [VerfasserIn] |
|---|
| | Kuner, Rohini [VerfasserIn] |
|---|
| | Heppenstall, Paul A. [VerfasserIn] |
|---|
| | Knipper, Marlies [VerfasserIn] |
|---|
| | Hu, Jing [VerfasserIn] |
|---|
| Titel: | Presynaptic GABAergic inhibition regulated by BDNF contributes to neuropathic pain induction |
|---|
| Verf.angabe: | Jeremy Tsung-chieh Chen, Da Guo, Dario Campanelli, Flavia Frattini, Florian Mayer, Luming Zhou, Rohini Kuner, Paul A. Heppenstall, Marlies Knipper & Jing Hu |
|---|
| E-Jahr: | 2014 |
|---|
| Jahr: | 30 October 2014 |
|---|
| Fussnoten: | Gesehen am 16.07.2020 |
|---|
| Titel Quelle: | Enthalten in: Nature Communications |
|---|
| Ort Quelle: | [London] : Nature Publishing Group UK, 2010 |
|---|
| Jahr Quelle: | 2014 |
|---|
| Band/Heft Quelle: | 5(2014) Artikel-Nummer 5331, 14 Seiten |
|---|
| ISSN Quelle: | 2041-1723 |
|---|
| Abstract: | The gate control theory proposes the importance of both pre- and post-synaptic inhibition in processing pain signal in the spinal cord. However, although postsynaptic disinhibition caused by brain-derived neurotrophic factor (BDNF) has been proved as a crucial mechanism underlying neuropathic pain, the function of presynaptic inhibition in acute and neuropathic pain remains elusive. Here we show that a transient shift in the reversal potential (EGABA) together with a decline in the conductance of presynaptic GABAA receptor result in a reduction of presynaptic inhibition after nerve injury. BDNF mimics, whereas blockade of BDNF signalling reverses, the alteration in GABAA receptor function and the neuropathic pain syndrome. Finally, genetic disruption of presynaptic inhibition leads to spontaneous development of behavioural hypersensitivity, which cannot be further sensitized by nerve lesions or BDNF. Our results reveal a novel effect of BDNF on presynaptic GABAergic inhibition after nerve injury and may represent new strategy for treating neuropathic pain. |
|---|
| DOI: | doi:10.1038/ncomms6331 |
|---|
| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1038/ncomms6331 |
|---|
| | Volltext: https://www.nature.com/articles/ncomms6331 |
|---|
| | DOI: https://doi.org/10.1038/ncomms6331 |
|---|
| Datenträger: | Online-Ressource |
|---|
| Sprache: | eng |
|---|
| K10plus-PPN: | 1724967169 |
|---|
| Verknüpfungen: | → Zeitschrift |
|---|
Presynaptic GABAergic inhibition regulated by BDNF contributes to neuropathic pain induction / Chen, Jeremy Tsung-Chieh [VerfasserIn]; 30 October 2014 (Online-Ressource)
