Status: Bibliographieeintrag
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| |  Online-Ressource |
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| Verfasst von: | Denzer, Lea [VerfasserIn]  |
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| | Schroten, Horst [VerfasserIn] |
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| | Schwerk, Christian [VerfasserIn] |
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| Titel: | From gene to protein-how bacterial virulence factors manipulate host gene expression during infection |
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| Verf.angabe: | Lea Denzer, Horst Schroten and Christian Schwerk |
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| E-Jahr: | 2020 |
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| Jahr: | 25 May 2020 |
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| Umfang: | 37 S. |
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| Fussnoten: | Gesehen am 23.07.2020 |
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| Titel Quelle: | Enthalten in: International journal of molecular sciences |
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| Ort Quelle: | Basel : Molecular Diversity Preservation International, 2000 |
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| Jahr Quelle: | 2020 |
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| Band/Heft Quelle: | 21(2020), 10, Seite 1-37 |
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| ISSN Quelle: | 1422-0067 |
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| | 1661-6596 |
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| Abstract: | Bacteria evolved many strategies to survive and persist within host cells. Secretion of bacterial effectors enables bacteria not only to enter the host cell but also to manipulate host gene expression to circumvent clearance by the host immune response. Some effectors were also shown to evade the nucleus to manipulate epigenetic processes as well as transcription and mRNA procession and are therefore classified as nucleomodulins. Others were shown to interfere downstream with gene expression at the level of mRNA stability, favoring either mRNA stabilization or mRNA degradation, translation or protein stability, including mechanisms of protein activation and degradation. Finally, manipulation of innate immune signaling and nutrient supply creates a replicative niche that enables bacterial intracellular persistence and survival. In this review, we want to highlight the divergent strategies applied by intracellular bacteria to evade host immune responses through subversion of host gene expression via bacterial effectors. Since these virulence proteins mimic host cell enzymes or own novel enzymatic functions, characterizing their properties could help to understand the complex interactions between host and pathogen during infections. Additionally, these insights could propose potential targets for medical therapy. |
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| DOI: | doi:10.3390/ijms21103730 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.3390/ijms21103730 |
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| | DOI: https://doi.org/10.3390/ijms21103730 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | bacteria |
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| | cell-like cells |
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| | endoplasmic-reticulum |
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| | gene expression |
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| | helicobacter-pylori |
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| | host-pathogen interaction |
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| | immune response |
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| | inflammation |
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| | inflammatory response |
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| | long noncoding rnas |
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| | manipulation |
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| | messenger-rna |
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| | mycobacterium-tuberculosis |
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| | nf-kappa-b |
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| | non-cpg methylation |
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| | persistence |
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| | polymerase-ii transcription |
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| | replicative niche |
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| | virulence factors |
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| K10plus-PPN: | 1725387638 |
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| Verknüpfungen: | → Zeitschrift |
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From gene to protein-how bacterial virulence factors manipulate host gene expression during infection / Denzer, Lea [VerfasserIn]; 25 May 2020 (Online-Ressource)
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