| |  Online-Ressource |
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| Verfasst von: | Karbiener, Michael [VerfasserIn]  |
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| | Pisani, Didier F. [VerfasserIn] |
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| | Frontini, Andrea [VerfasserIn] |
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| | Oberreiter, Lisa M. [VerfasserIn] |
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| | Lang, Eleonore [VerfasserIn] |
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| | Vegiopoulos, Alexandros [VerfasserIn] |
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| | Mössenböck, Karin [VerfasserIn] |
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| | Bernhardt, Gerwin A. [VerfasserIn] |
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| | Mayr, Torsten [VerfasserIn] |
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| | Hildner, Florian [VerfasserIn] |
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| | Grillari, Johannes [VerfasserIn] |
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| | Ailhaud, Gérard [VerfasserIn] |
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| | Herzig, Stephan [VerfasserIn] |
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| | Cinti, Saverio [VerfasserIn] |
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| | Amri, Ez-Zoubir [VerfasserIn] |
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| | Scheideler, Marcel [VerfasserIn] |
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| Titel: | MicroRNA-26 family is required for human adipogenesis and drives characteristics of brown adipocytes |
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| Verf.angabe: | Michael Karbiener, Didier F. Pisani, Andrea Frontini, Lisa M. Oberreiter, Eleonore Lang, Alexandros Vegiopoulos, Karin Mössenböck, Gerwin A. Bernhardt, Torsten Mayr, Florian Hildner, Johannes Grillari, Gérard Ailhaud, Stephan Herzig, Saverio Cinti, Ez-Zoubir Amri, Marcel Scheideler |
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| Jahr: | 2014 |
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| Jahr des Originals: | 2013 |
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| Umfang: | 13 S. |
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| Fussnoten: | first published online in STEM CELLS EXPRESS December 3, 2013 ; Gesehen am 20.08.2020 |
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| Titel Quelle: | Enthalten in: Stem cells |
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| Ort Quelle: | Hoboken, NJ : Wiley-Blackwell, 1983 |
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| Jahr Quelle: | 2014 |
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| Band/Heft Quelle: | 32(2014), 6, Seite 1578-1590 |
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| ISSN Quelle: | 1549-4918 |
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| Abstract: | Adipose tissue contains thermogenic adipocytes (i.e., brown and brite/beige) that oxidize nutrients at exceptionally high rates via nonshivering thermogenesis. Its recent discovery in adult humans has opened up new avenues to fight obesity and related disorders such as diabetes. Here, we identified miR-26a and -26b as key regulators of human white and brite adipocyte differentiation. Both microRNAs are upregulated in early adipogenesis, and their inhibition prevented lipid accumulation while their overexpression accelerated it. Intriguingly, miR-26a significantly induced pathways related to energy dissipation, shifted mitochondrial morphology toward that seen in brown adipocytes, and promoted uncoupled respiration by markedly increasing the hallmark protein of brown fat, uncoupling protein 1. By combining in silico target prediction, transcriptomics, and an RNA interference screen, we identified the sheddase ADAM metallopeptidase domain 17 (ADAM17) as a direct target of miR-26 that mediated the observed effects on white and brite adipogenesis. These results point to a novel, critical role for the miR-26 family and its downstream effector ADAM17 in human adipocyte differentiation by promoting characteristics of energy-dissipating thermogenic adipocytes. Stem Cells 2014;32:1578-1590 |
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| DOI: | doi:10.1002/stem.1603 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1002/stem.1603 |
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| | Volltext: https://stemcellsjournals.onlinelibrary.wiley.com/doi/abs/10.1002/stem.1603 |
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| | DOI: https://doi.org/10.1002/stem.1603 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | ADAM17 |
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| | Adipocyte differentiation |
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| | Brite adipogenesis |
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| | MicroRNA-26 |
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| | White adipogenesis |
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| K10plus-PPN: | 1727515803 |
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| Verknüpfungen: | → Zeitschrift |
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MicroRNA-26 family is required for human adipogenesis and drives characteristics of brown adipocytes / Karbiener, Michael [VerfasserIn]; 2014 (Online-Ressource)
