Noncoding RNAs

• Verfasst von: Bali, Kiran Kumar [VerfasserIn]
• Verfasst von: Kuner, Rohini [VerfasserIn]
• Titel: Noncoding RNAs
• Titelzusatz: key molecules in understanding and treating pain
• Verf.angabe: Kiran Kumar Bali and Rohini Kuner
• E-Jahr: 2014
• Jahr: 28 June 2014
• Umfang: 12 S.
• Fussnoten: Gesehen am 04.09.2020
• Titel Quelle: Enthalten in: Trends in molecular medicine
• Ort Quelle: Amsterdam [u.a.] : Elsevier Science, 2001
• Jahr Quelle: 2014
• Band/Heft Quelle: 20(2014), 8, Seite 437-448
• ISSN Quelle: 1471-499X
• DOI: doi:10.1016/j.molmed.2014.05.006
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: chronic pain
• Sach-SW: lncRNA
• Sach-SW: miRNA
• Sach-SW: ncRNA
• Sach-SW: pain mechanisms
• K10plus-PPN: 1728865018

Abstract

Although noncoding RNAs (ncRNAs) were initially considered to be transcriptional byproducts, recent technological advances have led to a steady increase in our understanding of their importance in gene regulation and disease pathogenesis. In keeping with these developments, pain research is also experiencing rapid growth in the investigation of links between ncRNAs and pathological pain. Although the initial focus was on analyzing expression and dysregulation of candidate miRNAs, elucidation of other ncRNAs and ncRNA-mediated functional mechanisms in pain modulation has just commenced. Here we review the major ncRNA literature available to date with respect to pain modulation and discuss tools and opportunities available for testing the impact of other types of ncRNA on pain.