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Verfasst von:Ahlgren, Hanna Henrika [VerfasserIn]   i
 Bas Orth, Carlos [VerfasserIn]   i
 Freitag, H. Eckehard [VerfasserIn]   i
 Hellwig, Andrea [VerfasserIn]   i
 Ottersen, Ole Petter [VerfasserIn]   i
 Bading, Hilmar [VerfasserIn]   i
Titel:The nuclear calcium signaling target, activating transcription factor 3 (ATF3), protects against dendrotoxicity and facilitates the recovery of synaptic transmission after an excitotoxic insult
Verf.angabe:Hanna Ahlgren, Carlos Bas-Orth, H. Eckehard Freitag, Andrea Hellwig, Ole Petter Ottersen, and Hilmar Bading
E-Jahr:2014
Jahr:February 10, 2014
Umfang:13 S.
Fussnoten:Gesehen am 04.09.2020
Titel Quelle:Enthalten in: The journal of biological chemistry
Ort Quelle:Bethesda, Md. : Soc., 1905
Jahr Quelle:2014
Band/Heft Quelle:289(2014), 14, Seite 9970-9982
ISSN Quelle:1083-351X
Abstract:The focal swellings of dendrites (“dendritic beading”) are an early morphological hallmark of neuronal injury and dendrotoxicity. They are associated with a variety of pathological conditions, including brain ischemia, and cause an acute disruption of synaptic transmission and neuronal network function, which contribute to subsequent neuronal death. Here, we show that increased synaptic activity prior to excitotoxic injury protects, in a transcription-dependent manner, against dendritic beading. Expression of activating transcription factor 3 (ATF3), a nuclear calcium-regulated gene and member of the core gene program for acquired neuroprotection, can protect against dendritic beading. Conversely, knockdown of ATF3 exacerbates dendritic beading. Assessment of neuronal network functions using microelectrode array recordings revealed that hippocampal neurons expressing ATF3 were able to regain their ability for functional synaptic transmission and to participate in coherent neuronal network activity within 48 h after exposure to toxic concentrations of NMDA. Thus, in addition to attenuating cell death, synaptic activity and expression of ATF3 render hippocampal neurons more resistant to acute dendrotoxicity and loss of synapses. Dendroprotection can enhance recovery of neuronal network functions after excitotoxic insults.
DOI:doi:10.1074/jbc.M113.502914
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1074/jbc.M113.502914
 Volltext: http://www.jbc.org/content/289/14/9970
 DOI: https://doi.org/10.1074/jbc.M113.502914
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Calcium Signaling
 Cell Signaling
 Gene Expression
 Glutamate Receptors Ionotropic (AMPA, NMDA)
 Neurobiology
 Neurodegeneration
 Neuroprotection
 Neurotransmitters
 Signal Transduction
K10plus-PPN:1728884365
Verknüpfungen:→ Zeitschrift

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