Delayed contrast dynamics as marker of regional impairment in pulmonary fibrosis using 5D MRI - a pilot study

• Verfasst von: Buzan, Maria Teodora [VerfasserIn]
• Verfasst von: Wetscherek, Andreas [VerfasserIn]
• Verfasst von: Rank, Christopher M. [VerfasserIn]
• Verfasst von: Kreuter, Michael [VerfasserIn]
• Verfasst von: Heußel, Claus Peter [VerfasserIn]
• Verfasst von: Kachelrieß, Marc [VerfasserIn]
• Verfasst von: Dinkel, Julien [VerfasserIn]
• Titel: Delayed contrast dynamics as marker of regional impairment in pulmonary fibrosis using 5D MRI - a pilot study
• Verf.angabe: Maria TA Buzan, Andreas Wetscherek, Christopher M Rank, Michael Kreuter, Claus Peter Heussel, Marc Kachelrieß, Julien Dinkel
• E-Jahr: 2020
• Jahr: [2020]
• Umfang: 7 S.
• Illustrationen: Illustrationen
• Fussnoten: Gesehen am 25.09.2020
• Titel Quelle: Enthalten in: BJR
• Ort Quelle: Bognor Regis : Wiley, 1928
• Jahr Quelle: 2020
• Band/Heft Quelle: 93(2020) Artikel-Nummer 20190121, 7 Seiten
• ISSN Quelle: 1748-880X
• DOI: doi:10.1259/bjr.20190121
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1733765603

Abstract

Objective:To analyse delayed contrast dynamics of fibrotic lesions in interstitial lung disease (ILD) using five dimensional (5D) MRI and to correlate contrast dynamics with disease severity.Methods:20 patients (mean age: 71 years; M:F, 13:7), with chronic fibrosing ILD: n = 12 idiopathic pulmonary fibrosis (IPF) and n = 8 non-IPF, underwent thin-section multislice CT as part of the standard diagnostic workup and additionally MRI of the lung. 2 min after contrast injection, a radial gradient echo sequence with golden-angle spacing was acquired during 5 min of free-breathing, followed by 5D image reconstruction. Disease was categorized as severe or non-severe according to CT morphological regional severity. For each patient, 10 lesions were analysed.Results:IPF lesions showed later peak enhancement compared to non-IPF (severe: p = 0.01, non-severe: p = 0.003). Severe lesions showed later peak enhancement compared to non-severe lesions, in non-IPF (p = 0.04), but not in IPF (p = 0.35). There was a tendency towards higher accumulation and washout rates in IPF compared to non-IPF in non-severe disease. Severe lesions had lower washout rate than non-severe ones in both IPF (p = 0.003) and non-IPF (p = 0.005). Continuous contrast agent accumulation, without washout, was found only in IPF lesions.Conclusions:Contrast agent dynamics are influenced by type and severity of pulmonary fibrosis, which might enable a more thorough characterisation of disease burden. The regional impairment is of particular interest in the context of antifibrotic treatments and was characterised using a non-invasive, non-irradiating, free-breathing method.Advances in knowledge:Delayed contrast enhancement patterns allow the assessment of regional lung impairment which could represent different disease stages or phenotypes in ILD.