| |  Online-Ressource |
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| Verfasst von: | Bao, Qiu Ying [VerfasserIn]  |
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| | Hotz-Wagenblatt, Agnes [VerfasserIn] |
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| | Betts, Matthew J. [VerfasserIn] |
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| | Hipp, Michaela [VerfasserIn] |
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| | Hugo, Annette [VerfasserIn] |
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| | Pougialis, Georgios [VerfasserIn] |
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| | Lei-Rossmann, Janet [VerfasserIn] |
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| | Löchelt, Martin [VerfasserIn] |
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| Titel: | Shared and cell type-specific adaptation strategies of Gag and Env yield high titer bovine foamy virus variants |
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| Verf.angabe: | Qiuying Bao, Agnes Hotz-Wagenblatt, Matthew J. Betts, Michaela Hipp, Annette Hugo, Georgios Pougialis, Janet Lei-Rossmann, Martin Löchelt |
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| E-Jahr: | 2020 |
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| Jahr: | 13 March 2020 |
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| Umfang: | 6 S. |
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| Fussnoten: | Gesehen am 15.10.2020 |
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| Titel Quelle: | Enthalten in: Infection, genetics and evolution |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 2001 |
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| Jahr Quelle: | 2020 |
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| Band/Heft Quelle: | 82(2020) Artikel-Nummer 104287, 6 Seiten |
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| ISSN Quelle: | 1567-7257 |
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| Abstract: | During in vitro selection and evolution screens to adapt the tightly cell-associated bovine foamy virus BFV to high titer cell-free transmission, common, cell-type specific and concurrent adaptive changes in Gag and Env, the major players of foamy virus particle assembly and release, were detected. Upon early establishment of cell type-independent pioneering mutations in Env and, subsequently in Gag, a diverse virus pool emerged that was characterized by the occurrence of shared and additional cell type-specific exchanges. At late passages and saturated titers, remarkably homogeneous virus populations characterized by functionally important mutations developed which may be partly due to stochastic evolutionary events that occurred earlier during adaptation. Reverse genetics showed that defined mutations were functionally important for high titer cell-free transmission. |
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| DOI: | doi:10.1016/j.meegid.2020.104287 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/j.meegid.2020.104287 |
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| | Volltext: http://www.sciencedirect.com/science/article/pii/S1567134820301180 |
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| | DOI: https://doi.org/10.1016/j.meegid.2020.104287 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Cell-free transmission |
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| | Co-evolution and co-adaptation of genes |
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| | Foamy virus |
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| | Pioneering mutation |
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| | Stochastic evolution |
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| | Virus evolution |
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| K10plus-PPN: | 1735654337 |
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| Verknüpfungen: | → Zeitschrift |
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Shared and cell type-specific adaptation strategies of Gag and Env yield high titer bovine foamy virus variants / Bao, Qiu Ying [VerfasserIn]; 13 March 2020 (Online-Ressource)
