Diabetic polyneuropathy is associated with pathomorphological changes in human dorsal root ganglia

• Verfasst von: Jende, Johann [VerfasserIn]
• Verfasst von: Kender, Zoltán [VerfasserIn]
• Verfasst von: Rother, Christian [VerfasserIn]
• Verfasst von: Alvarez-Ramos, Lucia [VerfasserIn]
• Verfasst von: Gröner, Jan [VerfasserIn]
• Verfasst von: Pham, Mirko [VerfasserIn]
• Verfasst von: Morgenstern, Jakob [VerfasserIn]
• Verfasst von: Oikonomou, Dimitrios [VerfasserIn]
• Verfasst von: Hahn, Artur [VerfasserIn]
• Verfasst von: Jürchott, Alexander [VerfasserIn]
• Verfasst von: Hayes, Jennifer [VerfasserIn]
• Verfasst von: Heiland, Sabine [VerfasserIn]
• Verfasst von: Kopf, Stefan [VerfasserIn]
• Verfasst von: Nawroth, Peter Paul [VerfasserIn]
• Verfasst von: Bendszus, Martin [VerfasserIn]
• Verfasst von: Kurz, Felix T. [VerfasserIn]
• Titel: Diabetic polyneuropathy is associated with pathomorphological changes in human dorsal root ganglia
• Titelzusatz: a study using 3T MR neurography
• Verf.angabe: Johann M.E. Jende, Zoltan Kender, Christian Rother, Lucia Alvarez-Ramos, Jan B. Groener, Mirko Pham, Jakob Morgenstern, Dimitrios Oikonomou, Artur Hahn, Alexander Juerchott, Jennifer Kollmer, Sabine Heiland, Stefan Kopf, Peter P. Nawroth, Martin Bendszus and Felix T. Kurz
• E-Jahr: 2020
• Jahr: 25 September 2020
• Fussnoten: Gesehen am 10.11.2020
• Titel Quelle: Enthalten in: Frontiers in neuroscience
• Ort Quelle: Lausanne : Frontiers Research Foundation, 2007
• Jahr Quelle: 2020
• Band/Heft Quelle: 14(2020) Artikel-Nummer 570744, 9 Seiten
• ISSN Quelle: 1662-453X
• DOI: doi:10.3389/fnins.2020.570744
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Diabetic poly neuropathy (DPN)
• Sach-SW: Dorsal root ganglia (DRG)
• Sach-SW: Magnetic resonance neurography (MRN)
• Sach-SW: neuropathic pain
• Sach-SW: Peripheral Nervous System
• K10plus-PPN: 1738356248
• K10plus-PPN:
  Universitätsbibliothek
• Lokale URL UB: full text

Abstract

Diabetic neuropathy (DPN) is one of the most severe and yet most poorly understood complications of diabetes mellitus. In vivo imaging of dorsal root ganglia (DRG), a key structure for the understanding of DPN, has been restricted to animal studies. These have shown a correlation of decreased DRG volume with neuropathic symptom severity. Our objective was to investigate correlations of DRG morphology and signal characteristics at 3 Tesla (3T) magnetic resonance neurography (MRN) with clinical and serological data in diabetic patients with and without DPN. In this cross-sectional study, participants underwent 3T MRN of both L5 DRG using an isotropic 3D T2-weighted, fat-suppressed sequence with subsequent segmentation of DRG volume and analysis of normalized signal properties. Overall, 55 diabetes patients (669 years; 32 men; 30 with DPN) took part in this study. DRG volume was smaller in patients with severe DPN when compared to patients with mild or moderate DPN (134.721.86 vs. 170.149.22; p=0.040). In DPN patients, DRG volume was negatively correlated with the neuropathy disability score (r=-0.43; 95%CI=-0.66 to -0.14; p=0.02), a measure of neuropathy severity. DRG volume showed negative correlations with triglycerides (r=-0.40; 95%CI=-0.57 to -0.19; p=0.006), and LDL cholesterol (r=-0.33; 95%CI=-0.51 to -0.11; p=0.04). There was a strong positive correlation of normalized MR signal intensity (SI) with the neuropathy symptom score in the subgroup of patients with painful DPN (r=0.80; 95%CI=0.46 to 0.93; p=0.005). DRG SI was positively correlated with HbA1c levels (r=0.30; 95%CI=0.09 to 0.50; p=0.03) and the triglyceride/HDL ratio (r=0.40; 95%CI=0.19 to 0.57; p=0.007). In this first in vivo study, we found DRG morphological degeneration and signal increase in correlation with neuropathy severity. This elucidates the potential importance of MR-based DRG assessments in studying structural and functional changes in DPN.