Gene-environment interaction in hyperkinetic conduct disorder (HD + CD) as indicated by season of birth variations in dopamine receptor (DRD4) gene polymorphism

• Verfasst von: Seeger, Gert Emil [VerfasserIn]
• Verfasst von: Schloss, Patrick [VerfasserIn]
• Verfasst von: Schmidt, Martin H. [VerfasserIn]
• Verfasst von: Rüter-Jungfleisch, Almut [VerfasserIn]
• Verfasst von: Henn, Fritz A. [VerfasserIn]
• Titel: Gene-environment interaction in hyperkinetic conduct disorder (HD + CD) as indicated by season of birth variations in dopamine receptor (DRD4) gene polymorphism
• Verf.angabe: Gert Seeger, Patrick Schloss, Martin H Schmidt, Almut Rüter-Jungfleisch, Fritz A Henn
• E-Jahr: 2004
• Jahr: 15 June 2004
• Umfang: 5 S.
• Fussnoten: Gesehen am 11.11.2020
• Titel Quelle: Enthalten in: Neuroscience letters
• Ort Quelle: Amsterdam [u.a.] : Elsevier Science, 1975
• Jahr Quelle: 2004
• Band/Heft Quelle: 366(2004), 3, Seite 282-286
• ISSN Quelle: 1872-7972
• DOI: doi:10.1016/j.neulet.2004.05.049
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: ADHD
• Sach-SW: DRD4 receptor gene polymorphism
• Sach-SW: Environmental factors
• Sach-SW: Hyperkinetic disorder
• K10plus-PPN: 1738389685

Abstract

Recently, an interaction between season of birth and the expression of candidate genes has been suggested. Season of birth variations in tryptophan hydroxylase (TPH), the serotonin transporter (5-HTTLPR) and the dopamine D4 receptor (DRD4) gene polymorphisms are different for affective disorders and schizophrenia. The DRD4 gene has been postulated as a candidate gene for attention-deficit-hyperactivity disorder (ADHD), equivalent to hyperkinetic disorder (HD). The seven-repeat long variant of this gene (DRD4*7) in comparison to the short repeat variants of the DRD4 gene polymorphism, has been found to be associated with ADHD. A seasonal pattern of birth has also been proposed for different subtypes of ADHD. Therefore, in a subgroup of children with HD and conduct disorder (CD) and in healthy controls, we investigated a possible association between the DRD4*7 allele and HD + CD in association with the season of birth. Supporting this hypothesis, we found an interaction between the seasons of birth and the expression of the DRD4 candidate gene in children with HD + CD as well as in controls, which differ significantly from each other. Depending on the season of birth, children carrying the DRD4*7R allele showed different relative risks for developing HD + CD.