Maternal factor V Leiden and prothrombin mutations do not seem to contribute to the occurrence of two or more than two consecutive miscarriages in Caucasian patients

• Verfasst von: Baumann, Kristin [VerfasserIn]
• Verfasst von: Beuter-Winkler, Petra [VerfasserIn]
• Verfasst von: Hackethal, Andreas [VerfasserIn]
• Verfasst von: Strowitzki, Thomas [VerfasserIn]
• Verfasst von: Toth, Bettina [VerfasserIn]
• Verfasst von: Bohlmann, Michael K. [VerfasserIn]
• Titel: Maternal factor V Leiden and prothrombin mutations do not seem to contribute to the occurrence of two or more than two consecutive miscarriages in Caucasian patients
• Verf.angabe: Kristin Baumann, Petra Beuter‐Winkler, Andreas Hackethal, Thomas Strowitzki, Bettina Toth, Michael K. Bohlmann
• E-Jahr: 2013
• Jahr: 25 June 2013
• Umfang: 4 S.
• Fussnoten: Gesehen am 16.11.2020
• Titel Quelle: Enthalten in: American journal of reproductive immunology
• Ort Quelle: Oxford : Wiley Blackwell, 1980
• Jahr Quelle: 2013
• Band/Heft Quelle: 70(2013), 6, Seite 518-521
• ISSN Quelle: 1600-0897
• DOI: doi:10.1111/aji.12144
• Datenträger: Online-Ressource
• Sprache: eng
• Bibliogr. Hinweis: Erscheint auch als : Druck-Ausgabe: Maternal factor V Leiden and prothrombin mutations do not seem to contribute to the occurrence of two or more than two consecutive miscarriages in Caucasian patients. - 2013
• Sach-SW: Factor V Leiden mutation
• Sach-SW: MTHFR (C677T) polymorphism
• Sach-SW: prothrombin (G20210A) mutation
• Sach-SW: recurrent miscarriage
• Sach-SW: thrombophilia
• K10plus-PPN: 1738727726

Abstract

Background: We analysed the prevalence of the most common hereditary thrombophilia (hTP) - factor V Leiden (FVL) mutation, prothrombin 20210 G>A substitution (PT) - and the 677 C>T replacement in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene in Caucasian patients with a history of two and more consecutive recurrent miscarriages (RMs) as compared to healthy controls with an identical ethnic background and at least one live birth. Methods A multicenter analysis of three hTP was performed in 641 RM patients identically screened at specialized university centres. Results The study groups consisted of 240 patients with 2 (1) and 401 patients with >2 miscarriages (2) and were compared with 157 controls. There was no significant difference in the prevalence of the hTP between RM patients and controls nor within the two study groups. Subgroup analysis showed that the homozygous MTHFR polymorphism was significantly more prevalent in the study group 2 as compared to study group 1 (13.9 versus 7.9%, P = 0.02). Conclusion In Caucasians, maternal FVL or PT mutations do not seem to contribute to the pathophysiology of RM, irrespective of the number of miscarriages. However, the role of the homozygous MTHFR polymorphism merits further investigation.