| |  Online-Ressource |
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| Verfasst von: | Usener, Dirk [VerfasserIn]  |
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| | Schadendorf, Dirk [VerfasserIn] |
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| | Koch, Joachim [VerfasserIn] |
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| | Dübel, Stefan [VerfasserIn] |
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| | Eichmüller, Stefan B. [VerfasserIn] |
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| Titel: | cTAGE |
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| Titelzusatz: | a cutaneous T cell lymphoma associated antigen family with tumor-specific splicing |
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| Verf.angabe: | Dirk Usener, Dirk Schadendorf, Joachim Koch, Stefan Dübel, and Stefan Eichmüller |
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| E-Jahr: | 2015 |
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| Jahr: | 8 December 2015 |
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| Jahr des Originals: | 2003 |
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| Umfang: | 9 S. |
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| Fussnoten: | Elektronische Reproduktion der Druckausgabe ; Gesehen am 23.11.2020 |
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| Titel Quelle: | Enthalten in: The journal of investigative dermatology |
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| Ort Quelle: | Amsterdam : Elsevier, 1938 |
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| Jahr Quelle: | 2003 |
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| Band/Heft Quelle: | 121(2003), 1, Seite 198-206 |
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| ISSN Quelle: | 1523-1747 |
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| Abstract: | cTAGE-1 is a cutaneous-T-cell-lymphoma-specific tumor antigen recently identified by serologic identification of antigens by recombinant expression cloning. This study was aimed at identifying and characterizing related genes. Rapid amplification of cDNA ends and DNA screening led to five new members of the cTAGE gene family belonging to four different genes, two of which were differentially spliced (cTAGE-1/2 and cTAGE-5). Expression analysis using reverse transcription polymerase chain reaction revealed that cTAGE-1, cTAGE-1B, and cTAGE-5A expression was restricted to testis and tumor tissues, whereas the other cTAGE members were found in two to eight other normal tissues (of 27 tissues tested). Tumor-specific protein expression of cTAGE-5 was confirmed by Western blotting. Sero-reactivity against cTAGE-1, cTAGE-4, cTAGE-5A, and cTAGE-5B was found only in tumor patients (cutaneous T cell lymphoma and melanoma). The immunogenic epitope of cTAGE-1 was determined by using epitope mapping and sera of two cutaneous T cell lymphoma patients. Moreover, cTAGE-1, cTAGE-4, cTAGE-5A, and cTAGE-5B could be detected in most types of tumor tissues and cell lines at variable frequencies, including those of cutaneous T cell lymphoma, melanoma, head and neck squamous cell carcinoma, breast carcinoma, and colon carcinoma. We conclude that cTAGE-1 and cTAGE-5 are new cancer germline antigens and that tumor-specific splicing of cTAGE genes may lead to further candidate proteins for specific immunotherapy of cutaneous T cell lymphoma and other malignancies. |
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| DOI: | doi:10.1046/j.1523-1747.2003.12318.x |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1046/j.1523-1747.2003.12318.x |
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| | Volltext: http://www.sciencedirect.com/science/article/pii/S0022202X15303134 |
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| | DOI: https://doi.org/10.1046/j.1523-1747.2003.12318.x |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | cancer-testis antigens |
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| | CTCL |
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| | melanoma |
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| | sero-reactivity |
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| | tumor immunology |
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| K10plus-PPN: | 174040176X |
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| Verknüpfungen: | → Zeitschrift |
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