| Online-Ressource |
Verfasst von: | Rangrez, Ashraf Yusuf [VerfasserIn]  |
| Borlepawar, Ankush [VerfasserIn]  |
| Schmiedel, Nesrin [VerfasserIn]  |
| Deshpande, Anushka [VerfasserIn]  |
| Remes, Anca [VerfasserIn]  |
| Kumari, Manju [VerfasserIn]  |
| Bernt, Alexander [VerfasserIn]  |
| Christen, Lynn [VerfasserIn]  |
| Helbig, Andreas [VerfasserIn]  |
| Jungmann, Andreas [VerfasserIn]  |
| Sossalla, Samuel [VerfasserIn]  |
| Tholey, Andreas [VerfasserIn]  |
| Müller, Oliver J. [VerfasserIn]  |
| Frank, Derk [VerfasserIn]  |
| Frey, Norbert [VerfasserIn]  |
Titel: | The E3 ubiquitin ligase HectD3 attenuates cardiac hypertrophy and inflammation in mice |
Verf.angabe: | Ashraf Yusuf Rangrez, Ankush Borlepawar, Nesrin Schmiedel, Anushka Deshpande, Anca Remes, Manju Kumari, Alexander Bernt, Lynn Christen, Andreas Helbig, Andreas Jungmann, Samuel Sossalla, Andreas Tholey, Oliver J. Müller, Derk Frank & Norbert Frey |
E-Jahr: | 2020 |
Jahr: | 09 October 2020 |
Umfang: | 15 S. |
Fussnoten: | Gesehen am 02.12.2020 |
Titel Quelle: | Enthalten in: Communications biology |
Ort Quelle: | London : Springer Nature, 2018 |
Jahr Quelle: | 2020 |
Band/Heft Quelle: | 3(2020), Artikel-ID 562, Seite 1-15 |
ISSN Quelle: | 2399-3642 |
Abstract: | Myocardial inflammation has recently been recognized as a distinct feature of cardiac hypertrophy and heart failure. HectD3, a HECT domain containing E3 ubiquitin ligase has previously been investigated in the host defense against infections as well as neuroinflammation; its cardiac function however is still unknown. Here we show that HectD3 simultaneously attenuates Calcineurin-NFAT driven cardiomyocyte hypertrophy and the pro-inflammatory actions of LPS/interferon-γ via its cardiac substrates SUMO2 and Stat1, respectively. AAV9-mediated overexpression of HectD3 in mice in vivo not only reduced cardiac SUMO2/Stat1 levels and pathological hypertrophy but also largely abolished macrophage infiltration and fibrosis induced by pressure overload. Taken together, we describe a novel cardioprotective mechanism involving the ubiquitin ligase HectD3, which links anti-hypertrophic and anti-inflammatory effects via dual regulation of SUMO2 and Stat1. In a broader perspective, these findings support the notion that cardiomyocyte growth and inflammation are more intertwined than previously anticipated. |
DOI: | doi:10.1038/s42003-020-01289-2 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1038/s42003-020-01289-2 |
| Volltext: https://www.nature.com/articles/s42003-020-01289-2 |
| DOI: https://doi.org/10.1038/s42003-020-01289-2 |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1741687306 |
Verknüpfungen: | → Zeitschrift |
¬The¬ E3 ubiquitin ligase HectD3 attenuates cardiac hypertrophy and inflammation in mice / Rangrez, Ashraf Yusuf [VerfasserIn]; 09 October 2020 (Online-Ressource)